LSM10 and MIRLET7A1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		LSM10	MIRLET7A1
Description		LSM10, U7 small nuclear RNA associated	microRNA let-7a-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U7 SnRNP Cajal Body Nuclear Body Cytoplasmic U SnRNP Body Ribonucleoprotein Complex	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding Histone Pre-mRNA DCP Binding U7 SnRNA Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage RNA Splicing Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		SLBP independent Processing of Histone Pre-mRNAs RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Diseases
GWAS		Diverticulitis ( 28585551) Neutrophil count ( 29403010)
Interacting Genes		10 interacting genes: BMPR2 CLNS1A LSM11 LSM3 MIR10B MIR128-1 MIR20A MIRLET7A1 SLBP SMN1	101 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CPSF2 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC LSM10 LSM11 MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM4 RTCB SAFB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B TRIM25 TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		84967	406881
HPRD ID		14326
Ensembl ID		ENSG00000181817	ENSG00000199165
Uniprot IDs		Q969L4
PDB IDs		6V4X
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Gene Silencing By Inhibition Of Translation MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Positive Regulation Of MRNA Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulatory NcRNA-mediated Gene Silencing MRNA Processing Negative Regulation Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis MRNA 3'-end Processing By Stem-loop Binding And Cleavage Histone Pre-mRNA 3'end Processing Complex MRNA Metabolic Process MRNA Destabilization RNA Destabilization Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Proliferation Involved In Heart Morphogenesis MRNA 3'-UTR Binding RNA Processing Regulation Of Translation Histone MRNA Metabolic Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Migration Regulation Of Cell Motility MRNA 3'-end Processing Regulation Of Endothelial Cell Migration Regulation Of MRNA Stability Regulation Of Locomotion RNA Splicing, Via Transesterification Reactions Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression Spliceosomal SnRNP Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Outflow Tract Morphogenesis Negative Regulation Of Lipoprotein Transport Negative Regulation Of Cardioblast Proliferation RNA Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Osteoblast Differentiation Extracellular Space Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleus MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Cytoplasmic Stress Granule Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of Translation Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization RNA 3'-end Processing Regulation Of Macromolecule Metabolic Process MRNA Stabilization MiRNA Processing Regulation Of Primary Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Histone MRNA Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process TRNA Metabolic Process TRNA Aminoacylation Nucleolus Positive Regulation Of Gene Expression
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