HLTF and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		HLTF	WBP4
Description		helicase like transcription factor	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Membrane Nuclear Matrix Nuclear Replication Fork RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding DNA Translocase Activity Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	Protein Polyubiquitination DNA Repair Chromatin Organization DNA Damage Response Protein Ubiquitination MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Replication Fork Reversal	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		14 interacting genes: CDK9 CEBPA DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		6596	11193
HPRD ID		04461	16086
Ensembl ID		ENSG00000071794	ENSG00000120688
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	O75554
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS	2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Transcription Granulocyte Differentiation Embryonic Placenta Development Protein Ubiquitination Protein Modification By Small Protein Conjugation Host-mediated Activation Of Viral Process Post-translational Protein Modification Postreplication Repair Ubiquitin Conjugating Enzyme Activity Nucleic Acid Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Protein-DNA Complex Cellular Response To Wortmannin Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Cellular Response To Stress Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transcription Cis-regulatory Region Binding Transcription Repressor Complex P-TEFb Complex Response To Vitamin B2 C/EBP Complex Lumenal Side Of Lysosomal Membrane Response To Wortmannin Cholesterol Sulfotransferase Activity Error-free Postreplication DNA Repair Host-mediated Perturbation Of Viral Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mononuclear Cell Differentiation DNA Metabolic Process Positive Regulation Of Protein Localization To Chromatin CHOP-C/EBP Complex Regulation Of Protein Import UBC13-MMS2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP Binding Regulation Of Nucleobase-containing Compound Metabolic Process	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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