HLTF and WBP4

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		HLTF	WBP4
Gene Name		helicase-like transcription factor	WW domain binding protein 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Nucleoplasm Spliceosomal Complex Plasma Membrane Nuclear Speck
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity ATPase Activity Poly(A) RNA Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Protein Polyubiquitination Postreplication Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Modification	MRNA Cis Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 23266558)
Protein-Protein Interactions		14 interactors: CDK9 EEF1G EWSR1 HSPA8 PCNA SP1 SP3 SULT1C2 UBC UBE2A UBE2N UBE2V2 UBE2Z WBP4	44 interactors: BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DIAPH1 DNM2 EFTUD2 EWSR1 FUS HLTF HNRNPK HNRNPU HTATSF1 KHDRBS1 NONO PABPC1 PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B3 SF3B4 SFPQ SNRNP70 SNRPA SNRPB TCERG1 WAS WBP11 WIPF1 XRCC6 ZNF207
Entrez ID		6596	11193
HPRD ID		04461	16086
Ensembl ID		ENSG00000071794	ENSG00000120688
Uniprot IDs		Q05BZ6 Q14527	B7Z4M2 O75554
PDB IDs		2L1I 4HRE 4HRH	2DK1 2JXW
Enriched GO Terms of Interacting Partners?		Postreplication Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA Repair Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair Cellular Metabolic Process DNA Double-strand Break Processing Cellular Response To Stress Protein Ubiquitination Embryonic Process Involved In Female Pregnancy DNA Metabolic Process Protein Modification By Small Protein Conjugation Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Megakaryocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Definitive Hemopoiesis Positive Regulation Of DNA Metabolic Process Trophectodermal Cell Differentiation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Protein K63-linked Ubiquitination Response To Transforming Growth Factor Beta DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Histone Ubiquitination Positive Regulation Of Metabolic Process Viral Process Blastocyst Formation Embryonic Camera-type Eye Morphogenesis Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway DNA-templated Transcription, Initiation Embryonic Eye Morphogenesis Female Pregnancy Positive Regulation Of Viral Transcription Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process See more	MRNA Processing RNA Splicing RNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly MRNA 3'-splice Site Recognition Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process Cellular Macromolecular Complex Assembly Spliceosomal Complex Assembly Cellular Component Assembly MRNA Splice Site Selection Cellular Process Metabolic Process MRNA 3'-end Processing Transcription, DNA-templated RNA Biosynthetic Process RNA 3'-end Processing Spliceosomal SnRNP Assembly Posttranscriptional Regulation Of Gene Expression Attachment Of Spindle Microtubules To Kinetochore Rhythmic Process Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Translational Initiation Macromolecule Biosynthetic Process Positive Regulation Of Translation Actin Polymerization Or Depolymerization Negative Regulation Of Gene Expression MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of MRNA Processing Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Positive Regulation Of Gene Expression MRNA Polyadenylation Cellular Response To Osmotic Stress See more
Tagcloud ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b
Tagcloud (Difference) ?		672e aside attenuates bambi bmp5 brains cflar cohesion condensation disrupts encephalomalacia exons metacore null participates postpartum rad21 rad5 scc1 scgb3a1 seq smad7 smc2 snapshot tnfrsf6 transcriptome triggering unidentified wnt10b
Tagcloud (Intersection) ?