BMPR2 and BMP4

Number of citations of the paper that reports this interaction (PubMedID 7644468)
40

Data Source:
HPRD (in vitro, in vivo)

		BMPR2	BMP4
Description		bone morphogenetic protein receptor type 2	bone morphogenetic protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity Protein Serine/threonine Kinase Activator Activity BMP Receptor Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Blood Vessel Development Osteoblast Differentiation Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Mesoderm Formation Organ Induction Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Renal System Process Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Sinoatrial Node Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Transcription By RNA Polymerase II Germ Cell Development Endoderm Development Mesoderm Development Mesodermal Cell Fate Determination Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Cell Differentiation Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Ameloblast Differentiation Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Inner Ear Auditory Receptor Cell Differentiation Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Mesodermal Cell Differentiation Intermediate Mesodermal Cell Differentiation Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Smooth Muscle Tissue Development Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Bone Development Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lung Morphogenesis Lung Vasculature Development Epithelium Development Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Prostate Gland Morphogenesis Prostatic Bud Formation Muscle Tissue Development Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Coronary Vasculature Development Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Ureter Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Pericyte Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Primary MiRNA Processing Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by BMP	Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Germ layer formation at gastrulation Formation of lateral plate mesoderm Formation of intermediate mesoderm Formation of paraxial mesoderm Specification of primordial germ cells Formation of the nephric duct Formation of the ureteric bud Specification of the neural plate border
Drugs		Dibotermin alfa Fostamatinib	Calcium
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32154731 32203549) Urate levels ( 23263486)	Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chin dimples ( 27182965) Colorectal cancer ( 25990418 26151821 19011631) Colorectal cancer or advanced adenoma ( 30510241) Dental caries ( 23259602) Estimated glomerular filtration rate ( 31152163) Glomerular filtration rate (creatinine) ( 26831199) Heel bone mineral density ( 30598549 28869591) High myopia ( 31816047) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Logical memory (delayed recall) in normal cognition ( 29274321) Lung function (FEV1/FVC) ( 30804560) Monobrow thickness ( 26926045) Myopia ( 27182965) Optic cup area ( 25631615) Optic disc size ( 31809533) Parkinson's disease ( 19915575) Peak expiratory flow ( 30804560) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for body mass index ( 27195708)
Interacting Genes		53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 CRIPTO GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TWSG1 ZFYVE9
Entrez ID		659	652
HPRD ID		02880	00207
Ensembl ID		ENSG00000204217	ENSG00000125378
Uniprot IDs		Q13873	P12644 Q53XC5
PDB IDs		2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway BMP Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway BMP Receptor Activity Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Pattern Specification Process Cellular Response To BMP Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Osteoblast Differentiation Regionalization Activin Receptor Signaling Pathway Extracellular Space Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Growth Factor Binding Mesoderm Formation Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Biomineral Tissue Development Osteoblast Differentiation Positive Regulation Of Ossification Cellular Response To Growth Factor Stimulus Formation Of Primary Germ Layer Regulation Of Cell Communication Regulation Of Signaling Dorsal/ventral Pattern Formation Anterior/posterior Pattern Specification Animal Organ Morphogenesis Response To Growth Factor Cellular Developmental Process Cell Differentiation Positive Regulation Of Osteoblast Differentiation Signal Transduction Epithelial Cell Proliferation Developmental Process Regulation Of Bone Mineralization Extracellular Region Activin Receptor Activity, Type II
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