BMPR2 and ERBB4

		BMPR2	ERBB4
Description		bone morphogenetic protein receptor type 2	erb-b2 receptor tyrosine kinase 4
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Neuromuscular Junction Presynaptic Membrane Organelle Receptor Complex Postsynaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Neuregulin Receptor Activity Protein Homodimerization Activity GABA Receptor Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Positive Regulation Of Biosynthetic Process Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Neuron Differentiation Regulation Of Cell Migration Mammary Gland Development ERBB4 Signaling Pathway ERBB2-ERBB4 Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Cell Surface Negative Regulation Of Neuron Migration
Pathways		Signaling by BMP
Drugs		Dibotermin alfa Fostamatinib	Afatinib Fostamatinib Brigatinib Zanubrutinib
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32154731 32203549) Urate levels ( 23263486)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) Bell's palsy ( 33602968) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 28892062) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Depression ( 33859377) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gastroesophageal reflux disease ( 34187846) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty liver disease ( 31311600) Loneliness ( 29970889 31518406) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 26416764 32289280) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Response to antidepressants (symptom improvement) ( 33589590) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systemic lupus erythematosus ( 33272962) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)
Interacting Genes		53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	152 interacting genes: ABL1 ABL2 ADAM17 ALDOA ANKS1A ANKS1B BCAR3 BLK BTC CCN2 CD44 CDC25C CFL1 CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG ERG28 FAM241B FES FGR FKBP1A GABARAPL2 GRAP2 GRB10 GRB2 GRB7 HBEGF HCK HDAC6 HSH2D ILKAP INPPL1 IRF2BP2 ITCH ITK LCK LCP2 LRRC7 LYN MAGI3 MATK MTMR2 MTMR6 MTMR9 MUC1 MUC4 NCK1 NCK2 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PRDX5 PRRG4 PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 RTN4 S100A11 SELENOK SH2B1 SH2B2 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNTB1 SNTB2 SNX27 SOCS1 SOCS2 SOCS3 SOCS5 SOCS6 SRC STAP1 STAT5A STAT5B STYX SYK SYNM TAB1 TAB2 TEC TFAP2C TGFA TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TRO TVP23B TXK TXN VAV1 VAV2 VAV3 WWOX YAP1 YES1 ZAP70 ZNF532
Entrez ID		659	2066
HPRD ID		02880	02767
Ensembl ID		ENSG00000204217	ENSG00000178568
Uniprot IDs		Q13873	Q15303
PDB IDs		2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U 8U4I 8U4J 8U4K 8U4L
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phosphoprotein Phosphatase Activity Intracellular Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Regulation Of Signal Transduction Protein Tyrosine Phosphatase Activity Regulation Of Signaling Regulation Of Cell Communication Leukocyte Activation Protein Tyrosine Kinase Activity Cell Activation Positive Regulation Of Immune System Process Lymphocyte Activation T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Dephosphorylation Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Cell Adhesion Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Receptor Tyrosine Kinase Binding Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response ERBB2 Signaling Pathway Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Signal Transduction ERBB4 Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Signaling Pathway Plasma Membrane Activation Of Immune Response Positive Regulation Of Cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Fc Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?