BMP4 and HTRA1

Number of citations: 0 (PubMedID 14973287)
Data Source: HPRD (in vitro)

		BMP4	HTRA1
Name		bone morphogenetic protein 4	HtrA serine peptidase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity Protein Serine/threonine Kinase Activator Activity BMP Receptor Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Blood Vessel Development Osteoblast Differentiation Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Mesoderm Formation Organ Induction Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Renal System Process Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Sinoatrial Node Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Transcription By RNA Polymerase II Germ Cell Development Endoderm Development Mesoderm Development Mesodermal Cell Fate Determination Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Cell Differentiation Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Ameloblast Differentiation Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Inner Ear Auditory Receptor Cell Differentiation Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Mesodermal Cell Differentiation Intermediate Mesodermal Cell Differentiation Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Smooth Muscle Tissue Development Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Bone Development Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lung Morphogenesis Lung Vasculature Development Epithelium Development Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Prostate Gland Morphogenesis Prostatic Bud Formation Muscle Tissue Development Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Coronary Vasculature Development Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Ureter Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Pericyte Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Primary MiRNA Processing Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Germ layer formation at gastrulation Formation of lateral plate mesoderm Formation of intermediate mesoderm Formation of paraxial mesoderm Specification of primordial germ cells Formation of the nephric duct Formation of the ureteric bud Specification of the neural plate border	Degradation of the extracellular matrix
Drugs		Calcium	None
Diseases		Anophthalmia and microphthalmia (A/M)	Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Cataracts ( 34127677 ) Chin dimples ( 27182965 ) Colorectal cancer ( 25990418 26151821 19011631 ) Colorectal cancer or advanced adenoma ( 30510241 ) Dental caries ( 23259602 ) Estimated glomerular filtration rate ( 31152163 ) Glomerular filtration rate (creatinine) ( 26831199 ) Heel bone mineral density ( 30598549 28869591 ) High myopia ( 31816047 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Lung function (FEV1/FVC) ( 30804560 ) Monobrow thickness ( 26926045 ) Myopia ( 27182965 ) Optic cup area ( 25631615 ) Optic disc size ( 31809533 ) Parkinson's disease ( 19915575 ) Peak expiratory flow ( 30804560 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-to-hip ratio adjusted for body mass index ( 27195708 )	Advanced age-related macular degeneration ( 26691988 ) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807 ) Age-related macular degeneration (choroidal neovascularisation) ( 22705344 ) Age-related macular degeneration (CNV vs. GA) ( 22705344 ) Age-related macular degeneration (extreme sampling) ( 23577725 ) Age-related macular degeneration (geographic atrophy) ( 22705344 ) Age-related macular degeneration (MTAG) ( 32277175 ) Age-related macular degeneration (wet) ( 17053108 ) Coronary artery disease ( 33020668 29212778 ) Disease progression in age-related macular degeneration ( 29346644 ) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644 ) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644 ) Diverticular disease ( 30177863 ) Early age-related macular degeneration ( 32843070 ) Exudative age-related macular degeneration ( 25629512 ) Laterality in neovascular age-related macular degeneration ( 28775256 ) Lung function (FEV1/FVC) ( 30804560 30061609 ) Migraine ( 27322543 ) Myocardial infarction ( 33532862 ) Neovascular age-related macular degeneration ( 28703135 ) Refractive error ( 32231278 ) Systolic blood pressure ( 30578418 30224653 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 )
Interacting Genes		18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 CRIPTO GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TWSG1 ZFYVE9	22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP
Entrez ID		652	5654
HPRD ID		00207	03725
Ensembl ID		ENSG00000125378	ENSG00000166033
Uniprot IDs		P12644 Q53XC5	Q92743
PDB IDs		Not available	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway BMP Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway BMP Receptor Activity Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Pattern Specification Process Cellular Response To BMP Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Osteoblast Differentiation Regionalization Activin Receptor Signaling Pathway Extracellular Space Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Growth Factor Binding Mesoderm Formation Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Biomineral Tissue Development Osteoblast Differentiation Positive Regulation Of Ossification Cellular Response To Growth Factor Stimulus Formation Of Primary Germ Layer Regulation Of Cell Communication Regulation Of Signaling Dorsal/ventral Pattern Formation Anterior/posterior Pattern Specification Animal Organ Morphogenesis Response To Growth Factor Cellular Developmental Process Cell Differentiation Positive Regulation Of Osteoblast Differentiation Signal Transduction Epithelial Cell Proliferation Developmental Process Regulation Of Bone Mineralization Extracellular Region Activin Receptor Activity, Type II	Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway