BMPR2 and LSP1

Number of citations: 0 (PubMedID 15188402)
Data Source: HPRD (in vitro)

		BMPR2	LSP1
Name		bone morphogenetic protein receptor type 2	lymphocyte specific protein 1
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Actin Binding Protein Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways		Signaling by BMP	None
Drugs		Dibotermin alfa Fostamatinib	None
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494 ) Intelligence (MTAG) ( 29326435 ) Mean corpuscular hemoglobin ( 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) PR interval ( 32439900 ) Reticulocyte fraction of red cells ( 32888494 ) Triglyceride levels ( 32154731 32203549 ) Urate levels ( 23263486 )	Bladder cancer ( 24163127 ) Breast cancer ( 20453838 17529967 23535729 29059683 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Celiac disease ( 23936387 ) Central corneal thickness ( 32528159 ) Diastolic blood pressure ( 30487518 27618452 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hypertension ( 30487518 ) Inflammatory bowel disease ( 28067908 23128233 ) Lymphocyte count ( 32888494 ) Mammographic density (dense area) ( 25342443 ) Mean arterial pressure ( 29403010 30487518 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (antihypertensives) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Methadone dose in opioid dependence ( 28115739 ) Milk allergy ( 25710614 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Potassium levels ( 29403010 ) Pulse pressure ( 30578418 27841878 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Ulcerative colitis ( 28067908 21297633 )
Novel Interactors		7 novel interactors: CASP10 CASP8 CHRND ERBB4 HAT1 IGFBP2 RAB11FIP1	None recorded
Interacting Genes		53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		659	4046
HPRD ID		02880	01083
Ensembl ID		ENSG00000204217	ENSG00000130592
Uniprot IDs		Q13873	A8K7L8 P33241
PDB IDs		2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O	3BH8 4NO0 4NO2
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity	None