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BMPR2 and TOPBP1
Number of citations of the paper that reports this interaction (PubMedID
15188402
)
0
Data Source:
HPRD
(in vitro)
BMPR2
TOPBP1
Description
bone morphogenetic protein receptor type 2
DNA topoisomerase II binding protein 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleoplasm
Plasma Membrane
Caveola
Clathrin-coated Pit
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
Apical Plasma Membrane
Cell Junction
Axon
Dendrite
Neuronal Cell Body
Organelle
Receptor Complex
Cell Body
Condensed Nuclear Chromosome
Spindle Pole
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytoskeleton
Plasma Membrane
Actin Cytoskeleton
Nuclear Body
PML Body
Site Of Double-strand Break
BRCA1-B Complex
Site Of DNA Damage
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type II
Transferase Activity
Growth Factor Binding
BMP Binding
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Protein Tyrosine Kinase Binding
DNA Binding
Protein Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Phosphorylation-dependent Protein Binding
Chromatin-protein Adaptor Activity
Biological Process
Regulation Of Cell Growth
Blood Vessel Development
Osteoblast Differentiation
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Vasculature Development
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Tissue Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Regulation Of Lung Blood Pressure
Cell Differentiation
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Locomotion
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Stem Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Retina Development In Camera-type Eye
Limb Development
Endochondral Bone Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lung Vasculature Development
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Regulation Of Multicellular Organismal Development
DNA Replication Checkpoint Signaling
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Metabolic Process
DNA Replication Initiation
DNA Repair
Double-strand Break Repair
Chromatin Organization
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To Ionizing Radiation
Mitotic DNA Replication Checkpoint Signaling
Homologous Recombination
Chromosome Organization
Double-strand Break Repair Via Classical Nonhomologous End Joining
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Broken Chromosome Clustering
Protein Localization To Site Of Double-strand Break
Pathways
Signaling by BMP
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Dibotermin alfa
Fostamatinib
Diseases
GWAS
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32154731
32203549
)
Urate levels (
23263486
)
Iron status biomarkers (
19084217
)
Interacting Genes
53 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CCDC89
CES1
CRIPTO
CRYAB
CTBP1
DYNLT1
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HNRNPR
INHBA
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RABGGTA
SMURF1
SULT1E1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
30 interacting genes:
ABL1
AKT1
ATM
BMPR2
BRIP1
CDC45
CHEK1
CIP2A
CLSTN1
E2F1
ESR1
GINS1
HUS1
NFYA
PML
POLE
PPHLN1
PPP1CC
RAD1
RAD9A
RAI1
RBBP8
SMARCAD1
TBC1D4
TCFL5
TEX11
TOP2B
UBR5
USP13
ZBTB17
Entrez ID
659
11073
HPRD ID
02880
09678
Ensembl ID
ENSG00000204217
ENSG00000163781
Uniprot IDs
Q13873
A0A2R8YD63
A0AV47
A7E2X7
Q05BV8
Q92547
PDB IDs
2HLQ
3G2F
6UNP
7PPA
7PPB
7PPC
7U5O
1WF6
2XNH
2XNK
3AL2
3AL3
3JVE
3OLC
3PD7
3UEN
3UEO
6RML
6RMM
7CMZ
8OK2
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To BMP Stimulus
Positive Regulation Of Cartilage Development
Growth Factor Activity
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cartilage Development
Osteoblast Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Bone Mineralization
Regulation Of Multicellular Organismal Development
Heart Development
Cytokine Activity
Cellular Response To Growth Factor Stimulus
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Activity, Type I
Positive Regulation Of Ossification
Regulation Of Cell Differentiation
Response To Growth Factor
Positive Regulation Of Developmental Process
Cartilage Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Osteoblast Differentiation
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Regulation Of Ossification
Regulation Of Bone Mineralization
SMAD Binding
Cell Differentiation
Regulation Of Chondrocyte Differentiation
Animal Organ Development
Enzyme Activator Complex
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Endocardial Cushion Formation
BMP Receptor Binding
Cellular Developmental Process
Regulation Of Growth
Protein Kinase Activity
DNA Metabolic Process
Negative Regulation Of Cell Cycle
DNA Damage Response
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Cellular Response To Stress
Nucleoplasm
DNA Repair
Negative Regulation Of Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Chromosome
Macromolecule Metabolic Process
Checkpoint Clamp Complex
Negative Regulation Of Mitotic Cell Cycle
DNA Double-strand Break Processing
Intracellular Signal Transduction
Nucleus
Chromosome Organization
Regulation Of Mitotic Cell Cycle
Reproductive Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Cell Cycle Process
Homologous Recombination
Response To Stress
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Fibroblast Proliferation
Regulation Of Cellular Response To Stress
DNA Recombination
Cellular Senescence
DNA Replication Checkpoint Signaling
Regulation Of RNA Biosynthetic Process
Response To Ionizing Radiation
Regulation Of Double-strand Break Repair
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Mitotic DNA Integrity Checkpoint Signaling
Cellular Response To Ionizing Radiation
Response To Radiation
Regulation Of Nucleobase-containing Compound Metabolic Process
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Developmental Process Involved In Reproduction
Regulation Of RNA Metabolic Process
Regulation Of Fibroblast Proliferation
Regulation Of DNA Metabolic Process
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