BMP4 and CHRDL2

Number of citations of the paper that reports this interaction (PMID 14660436)
14

Data Source:
HPRD (in vivo)

		BMP4	CHRDL2
Gene Name		bone morphogenetic protein 4	chordin-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Space Cytoplasm
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Endocardial Cushion Development Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Germ Cell Development Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Extracellular Matrix Organization Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Renal System Development Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of DNA-dependent DNA Replication Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Ossification Cell Differentiation Negative Regulation Of BMP Signaling Pathway Cartilage Development
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Dental caries ( 23259602) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease ( 19915575) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		15 interactors: BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG SOSTDC1 STAP2 TWSG1 ZFYVE9	7 interactors: BMP2 BMP4 BMP5 BMP6 BMP7 GDF5 INHBA
Entrez ID		652	25884
HPRD ID		00207	09881
Ensembl ID		ENSG00000125378	ENSG00000054938
Uniprot IDs		P12644 Q53XC5	Q6WN34
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Connective Tissue Development Regulation Of Osteoblast Differentiation Organ Development Regulation Of Ossification Tissue Development Pattern Specification Process Mesoderm Formation Mesoderm Morphogenesis Multicellular Organismal Development Negative Regulation Of Chondrocyte Proliferation Anatomical Structure Development Skeletal System Development Ossification Sensory Organ Development Organ Morphogenesis Dorsal/ventral Pattern Formation Formation Of Primary Germ Layer Regulation Of Cytokine Activity Cell Surface Receptor Signaling Pathway System Development Mesoderm Development Developmental Process Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Proteoglycan Biosynthetic Process Limb Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of Epithelial Cell Proliferation Embryonic Morphogenesis Tissue Morphogenesis Cell Differentiation	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Cartilage Development Connective Tissue Development Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Neurogenesis Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Regulation Of Protein Phosphorylation Glandular Epithelial Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Skeletal System Development Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Proliferation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Proliferation Involved In Kidney Development Ossification Regulation Of Neurogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Death Regulation Of Cell Differentiation Regulation Of Cartilage Development Mesenchymal Cell Proliferation Positive Regulation Of DNA-dependent DNA Replication Positive Regulation Of Ossification Tissue Development Type B Pancreatic Cell Development Regulation Of Intracellular Signal Transduction Regulation Of Cell Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	affymetrix axin2 bglap2 bmp bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	affymetrix axin2 bglap2 bridge cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?		bmp