BMPR2 and TRPC1

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		BMPR2	TRPC1
Gene Name		bone morphogenetic protein receptor, type II (serine/threonine kinase)	transient receptor potential cation channel, subfamily C, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Sarcomere Costamere Receptor Complex Membrane Raft
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding	Cation Channel Activity Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Ion Channel Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process	Calcium Ion Transport Axon Guidance Ion Transmembrane Transport Saliva Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport
Pathways		Signaling by BMP	Signaling by the B Cell Receptor (BCR) Ion channel transport Axon guidance Role of second messengers in netrin-1 signaling TRP channels Stimuli-sensing channels Netrin-1 signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Urate levels ( 23263486)
Protein-Protein Interactions		49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	14 interactors: BMPR2 CAV1 GRIA1 HOMER1 HOMER3 ITPR2 ITPR3 MDFI MX1 PKD2 RHOA TRPC3 TRPC4 TRPC5
Entrez ID		659	7220
HPRD ID		02880	11894
Ensembl ID		ENSG00000204217	ENSG00000144935
Uniprot IDs		Q13873	P48995
PDB IDs		2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus	Vascular Endothelial Growth Factor Receptor Signaling Pathway Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Metal Ion Transport Positive Regulation Of Calcium Ion Transport Response To Stimulus Response To Calcium Ion Regulation Of Cellular Localization Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cation Transport Ion Transport Cell Communication Response To External Stimulus Blood Coagulation Hemostasis Regulation Of Intracellular Transport Ion Transmembrane Transport Platelet Activation Positive Regulation Of Ion Transport Response To Inorganic Substance Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cation Transmembrane Transport Cellular Response To Stimulus Regulation Of Signaling Regulation Of Cation Channel Activity Regulation Of Body Fluid Levels Regulation Of Endothelial Cell Proliferation Wound Healing Regulation Of Transcription Factor Import Into Nucleus Anatomical Structure Morphogenesis Regulation Of Ion Transport Regulation Of Protein Transport Transmembrane Transport Response To Organic Substance Response To Stress Regulation Of Establishment Of Protein Localization Response To Metal Ion Response To Wounding Intracellular Signal Transduction Positive Regulation Of Transport Positive Regulation Of Signal Transduction Inositol Phosphate-mediated Signaling Regulation Of Store-operated Calcium Entry G-protein Coupled Glutamate Receptor Signaling Pathway Axon Guidance
Tagcloud ?		apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap	ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl
Tagcloud (Difference) ?		apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap	ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc2 trpl
Tagcloud (Intersection) ?