BMP4 and TWSG1

Number of citations of the paper that reports this interaction (PMID 11260715)
41

Data Source:
BioGRID (pull down)

		BMP4	TWSG1
Gene Name		bone morphogenetic protein 4	twisted gastrulation BMP signaling modulator 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity BMP Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPKK Activity Osteoblast Differentiation Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Renal System Process BMP Signaling Pathway Involved In Heart Induction Secondary Heart Field Specification Endocardial Cushion Development Cardiac Septum Development Type B Pancreatic Cell Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Germ Cell Development Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Organ Position Regulation Of Cell Fate Commitment Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cell Death Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Extracellular Matrix Organization Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Regulation Of Protein Import Into Nucleus Negative Regulation Of Phosphorylation Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Intermediate Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Inner Ear Receptor Cell Differentiation Cloacal Septation Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Lung Morphogenesis Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Negative Regulation Of Cell Death Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Ureter Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation Pulmonary Artery Endothelial Tube Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Involved In Nephric Duct Formation Renal System Development Glomerular Visceral Epithelial Cell Development Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Mesenchymal Cell Differentiation Involved In Kidney Development Ureter Epithelial Cell Differentiation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Metanephric Collecting Duct Development Positive Regulation Of Kidney Development Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of DNA-dependent DNA Replication Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Ossification Mesoderm Formation Salivary Gland Morphogenesis Hemopoiesis Cell Differentiation BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Camera-type Eye Development Negative Regulation Of Osteoblast Differentiation
Pathways		Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Dental caries ( 23259602) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease ( 19915575) Primary tooth development (time to first tooth eruption) ( 23704328)	Dental caries ( 23064961)
Protein-Protein Interactions		15 interactors: BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 GREM2 HTRA1 NOG SOSTDC1 STAP2 TWSG1 ZFYVE9	4 interactors: BMP1 BMP4 CHRD SGTA
Entrez ID		652	57045
HPRD ID		00207	05443
Ensembl ID		ENSG00000125378	ENSG00000128791
Uniprot IDs		P12644 Q53XC5	Q9GZX9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cartilage Development Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Connective Tissue Development Regulation Of Osteoblast Differentiation Organ Development Regulation Of Ossification Tissue Development Pattern Specification Process Mesoderm Formation Mesoderm Morphogenesis Multicellular Organismal Development Negative Regulation Of Chondrocyte Proliferation Anatomical Structure Development Skeletal System Development Ossification Sensory Organ Development Organ Morphogenesis Dorsal/ventral Pattern Formation Formation Of Primary Germ Layer Regulation Of Cytokine Activity Cell Surface Receptor Signaling Pathway System Development Mesoderm Development Developmental Process Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation Proteoglycan Biosynthetic Process Limb Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of Epithelial Cell Proliferation Embryonic Morphogenesis Tissue Morphogenesis Cell Differentiation	Ossification Positive Regulation Of Cartilage Development Regulation Of Mesenchymal Cell Proliferation Skeletal System Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Mesoderm Formation Regulation Of Cartilage Development Mesoderm Morphogenesis Regulation Of Stem Cell Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Mesenchymal Cell Proliferation Involved In Ureter Development Ureter Epithelial Cell Differentiation Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Pulmonary Artery Endothelial Tube Morphogenesis BMP Signaling Pathway Involved In Renal System Segmentation BMP Signaling Pathway Involved In Ureter Morphogenesis Negative Regulation Of Branch Elongation Involved In Ureteric Bud Branching By BMP Signaling Pathway Specification Of Ureteric Bud Anterior/posterior Symmetry By BMP Signaling Pathway Positive Regulation Of Cardiac Muscle Fiber Development Bud Dilation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis BMP Signaling Pathway Involved In Nephric Duct Formation Intermediate Mesodermal Cell Differentiation Regulation Of Osteoblast Differentiation Formation Of Primary Germ Layer Osteoblast Differentiation Mesoderm Development Intermediate Mesoderm Development Gastrulation Neural Tube Development Cartilage Development Regulation Of Ossification Negative Regulation Of Glomerular Mesangial Cell Proliferation Ureter Urothelium Development Mesenchymal Cell Proliferation Involved In Ureteric Bud Development Cloacal Septation Negative Regulation Of Glomerulus Development Mesodermal Cell Fate Determination BMP Signaling Pathway Involved In Heart Induction Deltoid Tuberosity Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Ureter Morphogenesis Ureter Smooth Muscle Cell Differentiation Regulation Of Branch Elongation Involved In Ureteric Bud Branching
Tagcloud ?		agonists antagonists apoptosis bmp2 causes complete controlling directly embryonal example exert identification induce malignant members p19 prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	acted anomaly bmp bmp2 concert dams e11 e9 embryonal expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt p19 penetrance predisposing teratogenesis twisted
Tagcloud (Difference) ?		agonists antagonists apoptosis causes complete controlling directly example exert identification induce malignant members prevents ra regulate requires retinoic retinoid retinoids specifically sufficient synergize transforming variety	acted anomaly concert dams e11 e9 expressivity forebrain gastrulation gavage geometric holoprosencephaly hpe manifested microct midface midline morphometric narrowing ntd overt penetrance predisposing teratogenesis twisted
Tagcloud (Intersection) ?		bmp bmp2 embryonal p19