BMPR2 and GDF6

Number of citations of the paper that reports this interaction (PubMedID 9525338)
0

Data Source:
HPRD (in vitro)

		BMPR2	GDF6
Description		bone morphogenetic protein receptor type 2	growth differentiation factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Cytokine Activity Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development	Metanephros Development Apoptotic Process Epithelial Cell Migration BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Cell Migration Involved In Metanephros Development Fat Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of P38MAPK Cascade Retinal Cell Apoptotic Process
Pathways		Signaling by BMP
Drugs		Dibotermin alfa Fostamatinib
Diseases			Anophthalmia and microphthalmia (A/M) Klippel-Feil syndrome(KFS)
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32154731 32203549) Urate levels ( 23263486)
Interacting Genes		53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	5 interacting genes: BMPR1A BMPR1B BMPR2 SMAD1 SMAD5
Entrez ID		659	392255
HPRD ID		02880	11002
Ensembl ID		ENSG00000204217	ENSG00000156466
Uniprot IDs		Q13873	A0A0S2A5D6 Q6KF10
PDB IDs		2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity	Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Osteoblast Differentiation Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Receptor Activity Cardiac Muscle Tissue Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Cartilage Development Cardiac Conduction System Development Stem Cell Differentiation BMP Binding Striated Muscle Tissue Development Muscle Tissue Development Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Bone Mineralization Osteoblast Fate Commitment Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Cell Differentiation Mullerian Duct Regression Tricuspid Valve Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Bone Development Regulation Of Cartilage Development Regulation Of Bone Mineralization Endochondral Bone Morphogenesis SMAD Protein Complex HFE-transferrin Receptor Complex Mitral Valve Morphogenesis Heteromeric SMAD Protein Complex DEAD/H-box RNA Helicase Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Developmental Process Reproductive Process Regulation Of Ossification Animal Organ Development Pharyngeal Arch Artery Morphogenesis Anatomical Structure Morphogenesis
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