BMPR2 and INHBA

Number of citations of the paper that reports this interaction (PubMedID 24018044)
0

Data Source:
BioGRID (pull down)

		BMPR2	INHBA
Description		bone morphogenetic protein receptor type 2	inhibin subunit beta A
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Membrane Apical Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Organelle Receptor Complex Cell Body	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm Enzyme Activator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Growth Factor Binding BMP Binding Cadherin Binding Metal Ion Binding BMP Receptor Activity Protein Tyrosine Kinase Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding
	Biological Process	Regulation Of Cell Growth Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Vasculature Development Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Tissue Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Regulation Of Lung Blood Pressure Cell Differentiation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Population Proliferation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Stem Cell Differentiation Negative Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lung Vasculature Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Regulation Of Multicellular Organismal Development	Ovarian Follicle Development Mesoderm Formation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Biosynthetic Process Autophagy Defense Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Steroid Metabolic Process Androgen Metabolic Process Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Type II Interferon Production Activin Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Animal Organ Development System Development Positive Regulation Of Protein Metabolic Process Sertoli Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Cardiac Fibroblast Cell Development Eyelid Development In Camera-type Eye Testosterone Biosynthetic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Hypoxia Cellular Response To Oxygen-glucose Deprivation GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Androst-4-ene-3,17-dione Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by BMP	Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones Antagonism of Activin by Follistatin TGFBR3 regulates activin signaling
Drugs		Dibotermin alfa Fostamatinib	Garetosmab
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32154731 32203549) Urate levels ( 23263486)	Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 21102462 25231870 27182965) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)
Interacting Genes		53 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRIPTO CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR INHBA INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SMURF1 SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	15 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B BMPR2 CFTR CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		659	3624
HPRD ID		02880	00929
Ensembl ID		ENSG00000204217	ENSG00000122641
Uniprot IDs		Q13873	A4D1W7 P08476
PDB IDs		2HLQ 3G2F 6UNP 7PPA 7PPB 7PPC 7U5O	1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ 6Y6N 6Y6O 7OLY 7U5P 9I5W
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Growth Factor Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cartilage Development Osteoblast Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Bone Mineralization Regulation Of Multicellular Organismal Development Heart Development Cytokine Activity Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Ossification Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Developmental Process Cartilage Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Osteoblast Differentiation Regulation Of Developmental Process Positive Regulation Of Signal Transduction Regulation Of Ossification Regulation Of Bone Mineralization SMAD Binding Cell Differentiation Regulation Of Chondrocyte Differentiation Animal Organ Development Enzyme Activator Complex Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Endocardial Cushion Formation BMP Receptor Binding Cellular Developmental Process Regulation Of Growth Protein Kinase Activity	Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Development Positive Regulation Of SMAD Protein Signal Transduction Inhibin-betaglycan-ActRII Complex Activin Receptor Activity, Type II Positive Regulation Of Biomineral Tissue Development Inhibin Binding Activin Receptor Activity BMP Binding Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Receptor Complex Activin Receptor Activity, Type I BMP Receptor Activity Positive Regulation Of Multicellular Organismal Process Cell Surface Positive Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Multicellular Organismal Process Animal Organ Development Positive Regulation Of Ossification Extracellular Space Coreceptor Activity Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Odontogenesis Of Dentin-containing Tooth
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?