BMP4 and NOG

Number of citations: 0 (PubMedID 10657699)
Data Source: HPRD (in vivo)

		BMP4	NOG
Name		bone morphogenetic protein 4	noggin
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Presynapse
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity Protein Serine/threonine Kinase Activator Activity BMP Receptor Binding	Protein Binding Growth Factor Binding Protein Homodimerization Activity Receptor Ligand Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Blood Vessel Development Osteoblast Differentiation Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Mesoderm Formation Organ Induction Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Renal System Process Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Sinoatrial Node Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Transcription By RNA Polymerase II Germ Cell Development Endoderm Development Mesoderm Development Mesodermal Cell Fate Determination Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Cell Differentiation Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Ameloblast Differentiation Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Inner Ear Auditory Receptor Cell Differentiation Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Mesodermal Cell Differentiation Intermediate Mesodermal Cell Differentiation Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Smooth Muscle Tissue Development Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Bone Development Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lung Morphogenesis Lung Vasculature Development Epithelium Development Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Prostate Gland Morphogenesis Prostatic Bud Formation Muscle Tissue Development Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Coronary Vasculature Development Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Ureter Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Pericyte Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Primary MiRNA Processing Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation Urogenital System Development Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Membranous Septum Morphogenesis Outflow Tract Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Smoothened Signaling Pathway Pattern Specification Process Nervous System Development Axon Guidance Central Nervous System Development Brain Development Endoderm Development Mesoderm Development Motor Neuron Axon Guidance Cell Population Proliferation Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Spinal Cord Development Cell Differentiation In Hindbrain Neural Tube Development Pituitary Gland Development Neural Plate Anterior/posterior Regionalization Cell Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Somatic Stem Cell Population Maintenance Exploration Behavior Nodal Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neuronal Synaptic Plasticity Axial Mesoderm Development Embryonic Organ Morphogenesis Notochord Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Atrial Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Long-term Synaptic Potentiation Face Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Negative Regulation Of Cartilage Development Somite Development Heart Trabecula Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Presynaptic Modulation Of Chemical Synaptic Transmission Cranial Skeletal System Development Short-term Synaptic Potentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Germ layer formation at gastrulation Formation of lateral plate mesoderm Formation of intermediate mesoderm Formation of paraxial mesoderm Specification of primordial germ cells Formation of the nephric duct Formation of the ureteric bud Specification of the neural plate border	Signaling by BMP Formation of paraxial mesoderm
Drugs		Calcium	None
Diseases		Anophthalmia and microphthalmia (A/M)	Stapes ankylosis with broad thumb and toes Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Tarsal-carpal coalition syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Cataracts ( 34127677 ) Chin dimples ( 27182965 ) Colorectal cancer ( 25990418 26151821 19011631 ) Colorectal cancer or advanced adenoma ( 30510241 ) Dental caries ( 23259602 ) Estimated glomerular filtration rate ( 31152163 ) Glomerular filtration rate (creatinine) ( 26831199 ) Heel bone mineral density ( 30598549 28869591 ) High myopia ( 31816047 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Lung function (FEV1/FVC) ( 30804560 ) Monobrow thickness ( 26926045 ) Myopia ( 27182965 ) Optic cup area ( 25631615 ) Optic disc size ( 31809533 ) Parkinson's disease ( 19915575 ) Peak expiratory flow ( 30804560 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-to-hip ratio adjusted for body mass index ( 27195708 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Celiac disease ( 23936387 ) Height ( 18391951 20881960 31562340 ) Metabolite levels ( 23823483 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Orofacial clefts ( 20023658 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 CRIPTO GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TWSG1 ZFYVE9	4 interacting genes: BMP2 BMP4 BMP5 BMP7
Entrez ID		652	9241
HPRD ID		00207	04291
Ensembl ID		ENSG00000125378	ENSG00000183691
Uniprot IDs		P12644 Q53XC5	Q13253
PDB IDs		Not available	1M4U 7AG0
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway BMP Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway BMP Receptor Activity Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Pattern Specification Process Cellular Response To BMP Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Osteoblast Differentiation Regionalization Activin Receptor Signaling Pathway Extracellular Space Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Growth Factor Binding Mesoderm Formation Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Biomineral Tissue Development Osteoblast Differentiation Positive Regulation Of Ossification Cellular Response To Growth Factor Stimulus Formation Of Primary Germ Layer Regulation Of Cell Communication Regulation Of Signaling Dorsal/ventral Pattern Formation Anterior/posterior Pattern Specification Animal Organ Morphogenesis Response To Growth Factor Cellular Developmental Process Cell Differentiation Positive Regulation Of Osteoblast Differentiation Signal Transduction Epithelial Cell Proliferation Developmental Process Regulation Of Bone Mineralization Extracellular Region Activin Receptor Activity, Type II	BMP Receptor Binding Positive Regulation Of SMAD Protein Signal Transduction Ameloblast Differentiation Regulation Of SMAD Protein Signal Transduction BMP Signaling Pathway Endocardial Cushion Formation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cartilage Development Regulation Of Epithelial To Mesenchymal Transition Ossification Growth Factor Activity Muscle Tissue Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Skeletal System Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Animal Organ Formation Cellular Response To BMP Stimulus Cytokine Activity Positive Regulation Of Bone Mineralization Heart Development Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Negative Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neural Fold Elevation Formation Morphogenesis Of An Epithelium Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Aldosterone Biosynthetic Process Cardiac Jelly Development Negative Regulation Of Cortisol Biosynthetic Process Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Epithelial Cell Differentiation Cardiac Muscle Tissue Development Negative Regulation Of Prostatic Bud Formation Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Allantois Development Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Osteoblast Differentiation Pattern Specification Process Cardiac Septum Morphogenesis Tissue Morphogenesis Regulation Of Bone Mineralization Regulation Of Animal Organ Morphogenesis Negative Regulation Of Glucocorticoid Biosynthetic Process Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Epithelial To Mesenchymal Transition Telencephalon Regionalization