BMP4 and PRKCH

Data Source: HiPPIP (Novel)

		BMP4	PRKCH
Name		bone morphogenetic protein 4	protein kinase C eta
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Co-receptor Binding Chemoattractant Activity Protein Serine/threonine Kinase Activator Activity BMP Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Translation Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Ossification Angiogenesis Blood Vessel Development Osteoblast Differentiation Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Mesoderm Formation Organ Induction Kidney Development Mesonephros Development Neural Tube Closure Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Vasculature Development Endochondral Ossification Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Myeloid Leukocyte Differentiation Heart Morphogenesis Renal System Process Heart Induction Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Sinoatrial Node Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Endocardial Cushion Morphogenesis Cardiac Septum Development Type B Pancreatic Cell Development Transcription By RNA Polymerase II Germ Cell Development Endoderm Development Mesoderm Development Mesodermal Cell Fate Determination Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Post-embryonic Development Anterior/posterior Axis Specification Specification Of Animal Organ Position Regulation Of Cell Fate Commitment Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Development Dorsal/ventral Neural Tube Patterning Telencephalon Regionalization Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Cell Differentiation Erythrocyte Differentiation Monocyte Differentiation Macrophage Differentiation Lung Development Embryonic Limb Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Positive Regulation Of Protein Binding Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Embryonic Hindlimb Morphogenesis Tendon Cell Differentiation Deltoid Tuberosity Development Ameloblast Differentiation Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Of Dentin-containing Tooth Inner Ear Auditory Receptor Cell Differentiation Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Fate Commitment Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Mesodermal Cell Differentiation Intermediate Mesodermal Cell Differentiation Camera-type Eye Morphogenesis Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development Smooth Muscle Tissue Development Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Cartilage Development Negative Regulation Of Multicellular Organismal Process Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Fiber Development Lens Induction In Camera-type Eye Embryonic Skeletal Joint Morphogenesis Bone Development Cranial Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Lung Morphogenesis Lung Vasculature Development Epithelium Development Bronchus Development Trachea Development Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Bud Elongation Involved In Lung Branching Epithelial Cell Proliferation Involved In Lung Morphogenesis Bud Dilation Involved In Lung Branching Prostate Gland Morphogenesis Prostatic Bud Formation Muscle Tissue Development Mammary Gland Formation Epithelial-mesenchymal Cell Signaling Negative Regulation Of Prostatic Bud Formation Regulation Of Branching Involved In Prostate Gland Morphogenesis Regulation Of Morphogenesis Of A Branching Structure Coronary Vasculature Development Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Positive Regulation Of Branching Involved In Lung Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Glomerular Capillary Formation Negative Regulation Of Glomerular Mesangial Cell Proliferation Nephric Duct Formation Ureter Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Glomerulus Development Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Odontoblast Differentiation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Pericyte Cell Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Cardiac Jelly Development Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Mesodermal Cell Differentiation Negative Regulation Of Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Comma-shaped Body Morphogenesis Positive Regulation Of Primary MiRNA Processing Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Translation Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Translation In Response To Stress Cellular Response To Amino Acid Starvation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly
Pathways		Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Germ layer formation at gastrulation Formation of lateral plate mesoderm Formation of intermediate mesoderm Formation of paraxial mesoderm Specification of primordial germ cells Formation of the nephric duct Formation of the ureteric bud Specification of the neural plate border	Effects of PIP2 hydrolysis G alpha (z) signalling events
Drugs		Calcium	None
Diseases		Anophthalmia and microphthalmia (A/M)	None
GWAS		Blond vs. brown/black hair color ( 30531825 ) Brain morphology (MOSTest) ( 32665545 ) Cataracts ( 34127677 ) Chin dimples ( 27182965 ) Colorectal cancer ( 25990418 26151821 19011631 ) Colorectal cancer or advanced adenoma ( 30510241 ) Dental caries ( 23259602 ) Estimated glomerular filtration rate ( 31152163 ) Glomerular filtration rate (creatinine) ( 26831199 ) Heel bone mineral density ( 30598549 28869591 ) High myopia ( 31816047 ) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502 ) Logical memory (delayed recall) in normal cognition ( 29274321 ) Lung function (FEV1/FVC) ( 30804560 ) Monobrow thickness ( 26926045 ) Myopia ( 27182965 ) Optic cup area ( 25631615 ) Optic disc size ( 31809533 ) Parkinson's disease ( 19915575 ) Peak expiratory flow ( 30804560 ) Primary tooth development (time to first tooth eruption) ( 23704328 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-to-hip ratio adjusted for body mass index ( 27195708 )	Asthma ( 32296059 ) Height ( 28552196 ) Obesity (early onset extreme) ( 23563609 ) Reading and spelling ( 23738518 ) Rheumatoid arthritis ( 22446963 24390342 30423114 ) Word reading ( 23738518 ) Yeast infection ( 28928442 )
Interacting Genes		18 interacting genes: ACVR2A BGN BMP8B BMPER BMPR1A BMPR1B BMPR2 CHRDL1 CHRDL2 CRIPTO GREM2 HTRA1 NOG RGMB SOSTDC1 STAP2 TWSG1 ZFYVE9	12 interacting genes: BANP CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS
Entrez ID		652	5583
HPRD ID		00207	05669
Ensembl ID		ENSG00000125378	ENSG00000027075
Uniprot IDs		P12644 Q53XC5	P24723
PDB IDs		Not available	2FK9 3TXO 8FP1 8FP3
GO Terms Enriched among Interactors		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway BMP Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway BMP Receptor Activity Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Pattern Specification Process Cellular Response To BMP Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cartilage Development Regulation Of Cellular Response To Growth Factor Stimulus Animal Organ Development Regulation Of Osteoblast Differentiation Regionalization Activin Receptor Signaling Pathway Extracellular Space Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Signal Transduction Growth Factor Binding Mesoderm Formation Pharyngeal Arch Artery Morphogenesis Positive Regulation Of Biomineral Tissue Development Osteoblast Differentiation Positive Regulation Of Ossification Cellular Response To Growth Factor Stimulus Formation Of Primary Germ Layer Regulation Of Cell Communication Regulation Of Signaling Dorsal/ventral Pattern Formation Anterior/posterior Pattern Specification Animal Organ Morphogenesis Response To Growth Factor Cellular Developmental Process Cell Differentiation Positive Regulation Of Osteoblast Differentiation Signal Transduction Epithelial Cell Proliferation Developmental Process Regulation Of Bone Mineralization Extracellular Region Activin Receptor Activity, Type II	Regulation Of Cellular Localization Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Establishment Of Protein Localization Response To Growth Factor Forebrain Development Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Integrin-mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization T Cell Costimulation Regulation Of Protein Localization To Nucleus Cellular Response To Hormone Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phospholipase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Regulation Of Neutrophil Activation Positive Regulation Of Protein Localization BMP Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neutrophil Activation Involved In Immune Response Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Adhesion Regulation Of Striated Muscle Cell Differentiation Protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intracellular Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Chemical Stress Negative Regulation Of Cell Cycle Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Differentiation Regulation Of Developmental Process Leukocyte Activation Tau-protein Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway