SLIT3 and CAPN1

Number of citations of the paper that reports this interaction (PMID 12358155)
3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLIT3	CAPN1
Gene Name		slit homolog 3 (Drosophila)	calpain 1, (mu/I) large subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Roundabout Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Axon Guidance Negative Regulation Of Cell Proliferation Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process
Pathways		Axon guidance Netrin-1 signaling	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		2 interactors: CAPN1 ROBO2	50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM
Entrez ID		6586	823
HPRD ID		04775	00253
Ensembl ID		ENSG00000184347	ENSG00000014216
Uniprot IDs		O75094	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Luteolysis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Receptor Catabolic Process Olfactory Bulb Interneuron Differentiation Negative Regulation Of Synapse Assembly Retinal Ganglion Cell Axon Guidance Negative Regulation Of Chemotaxis Apoptotic Process Involved In Development Forebrain Neuron Development Neuron Recognition Olfactory Bulb Development Olfactory Lobe Development Regulation Of Synapse Assembly Forebrain Neuron Differentiation Positive Regulation Of Axonogenesis Receptor Metabolic Process Forebrain Generation Of Neurons Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Extracellular Matrix Disassembly Ovulation Cycle Process Metanephros Development Central Nervous System Neuron Development Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cell Recognition Mesonephros Development Regulation Of Chemotaxis	Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress
Tagcloud ?		17beta 1h axonal dpn ec50 endometrial endometriosis erbeta estradiol ganglia guidance nerves neurite neuroangiogenesis neurogenesis neurovascular outgrowth painful pelvic peritoneum propionitrile propyl pyrazole robo roundabout suffer trisphenol tryl	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Difference) ?		17beta 1h axonal dpn ec50 endometrial endometriosis erbeta estradiol ganglia guidance nerves neurite neuroangiogenesis neurogenesis neurovascular outgrowth painful pelvic peritoneum propionitrile propyl pyrazole robo roundabout suffer trisphenol tryl	5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36
Tagcloud (Intersection) ?