SLIT3 and ROBO2

Number of citations of the paper that reports this interaction (PMID 11754167)
46

Data Source:
HPRD (in vitro, in vivo)

		SLIT3	ROBO2
Gene Name		slit homolog 3 (Drosophila)	roundabout, axon guidance receptor, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion	Cell Surface Integral Component Of Membrane Axolemma Extracellular Vesicular Exosome
	Molecular Function	Calcium Ion Binding Roundabout Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Axon Guidance Negative Regulation Of Cell Proliferation Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway	Metanephros Development Ureteric Bud Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Apoptotic Process Involved In Luteolysis
Pathways		Axon guidance Netrin-1 signaling	Axon guidance Regulation of Commissural axon pathfinding by Slit and Robo Signaling by Robo receptor
Drugs
Diseases
GWAS		Height ( 20881960)	Brain imaging in schizophrenia (interaction) ( 19023125) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000)
Protein-Protein Interactions		2 interactors: CAPN1 ROBO2	16 interactors: BNIP3L CENPU CPE HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TRIM13 UBQLN4
Entrez ID		6586	6092
HPRD ID		04775	11895
Ensembl ID		ENSG00000184347	ENSG00000185008
Uniprot IDs		O75094	Q9HCK4
PDB IDs			1UEM 1UJT 2EDJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Negative Chemotaxis Apoptotic Process Involved In Luteolysis Regulation Of Negative Chemotaxis Luteolysis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Receptor Catabolic Process Olfactory Bulb Interneuron Differentiation Negative Regulation Of Synapse Assembly Retinal Ganglion Cell Axon Guidance Negative Regulation Of Chemotaxis Apoptotic Process Involved In Development Forebrain Neuron Development Neuron Recognition Olfactory Bulb Development Olfactory Lobe Development Regulation Of Synapse Assembly Forebrain Neuron Differentiation Positive Regulation Of Axonogenesis Receptor Metabolic Process Forebrain Generation Of Neurons Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Extracellular Matrix Disassembly Ovulation Cycle Process Metanephros Development Central Nervous System Neuron Development Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cell Recognition Mesonephros Development Regulation Of Chemotaxis	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Chemotaxis Cell Migration Involved In Sprouting Angiogenesis Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Regulation Of Cytokine-mediated Signaling Pathway Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Regulation Of Negative Chemotaxis Luteolysis Response To Cortisol Sprouting Angiogenesis Mammary Duct Terminal End Bud Growth Signal Transduction Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cellular Response To Stimulus Olfactory Bulb Interneuron Development Axon Extension Involved In Axon Guidance Signaling Endothelial Cell Migration Cell Communication Chemotaxis Cerebral Cortex Tangential Migration Positive Regulation Of Cell Death Epithelial Cell Migration Epithelium Migration Olfactory Bulb Interneuron Differentiation Response To External Stimulus Axon Guidance Developmental Growth Involved In Morphogenesis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Chemotaxis Response To Stimulus Apoptotic Process Involved In Development Ameboidal-type Cell Migration Response To Steroid Hormone Regulation Of Cellular Process Regulation Of Protein Metabolic Process Forebrain Neuron Development Substrate-dependent Cell Migration Apoptotic Process Axonogenesis Olfactory Bulb Development Axon Extension Programmed Cell Death Cell Surface Receptor Signaling Pathway Olfactory Lobe Development Cell Death
Tagcloud ?		17beta 1h axonal dpn ec50 endometrial endometriosis erbeta estradiol ganglia guidance nerves neurite neuroangiogenesis neurogenesis neurovascular outgrowth painful pelvic peritoneum propionitrile propyl pyrazole robo roundabout suffer trisphenol tryl	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		17beta 1h axonal dpn ec50 endometrial endometriosis erbeta estradiol ganglia guidance nerves neurite neuroangiogenesis neurogenesis neurovascular outgrowth painful pelvic peritoneum propionitrile propyl pyrazole robo roundabout suffer trisphenol tryl	arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?