SLIT3 and ROBO2

Number of citations of the paper that reports this interaction (PubMedID 11754167)
0

Data Source:
HPRD (in vitro, in vivo)

		SLIT3	ROBO2
Description		slit guidance ligand 3	roundabout guidance receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome
	Molecular Function	Calcium Ion Binding Heparin Binding Roundabout Binding	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Nervous System Development Axon Guidance Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Differentiation Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud
Drugs
Diseases			Vesicoureteral reflux
GWAS		Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737) Bipolar disorder x sex interaction ( 34099189) Body mass index ( 31217584) Circulating leptin levels in high cardiovascular risk ( 31766143) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009) Gut microbiota (functional units) ( 27694959) Hallux valgus ( 32131869) Height ( 28552196 25429064 20881960 31562340 25282103) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Menarche (age at onset) ( 25231870) Non-word reading ( 30741946) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Treatment resistant depression ( 30468137)	Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		2 interacting genes: CAPN1 ROBO2	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		6586	6092
HPRD ID		04775	11895
Ensembl ID		ENSG00000184347	ENSG00000185008
Uniprot IDs		O75094	A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4
PDB IDs			1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?			Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis
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