SLIT3 and HRH2

Data Source: HiPPIP (Novel)

		SLIT3	HRH2
Name		slit guidance ligand 3	histamine receptor H2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Calcium Ion Binding Heparin Binding Roundabout Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Nervous System Development Axon Guidance Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Differentiation Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway	Gastric Acid Secretion Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Vasoconstriction
Pathways		Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO	Histamine receptors G alpha (s) signalling events
Drugs		None	Betazole Amitriptyline Loxapine Cyproheptadine Cimetidine Nizatidine Epinastine Olopatadine Tolazoline Ranitidine Famotidine Methantheline Azelastine Promethazine Doxepin Aripiprazole HZT-501 Histamine Asenapine Metiamide Roxatidine acetate Viloxazine Niperotidine
GWAS		Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 ) Bipolar disorder x sex interaction ( 34099189 ) Body mass index ( 31217584 ) Circulating leptin levels in high cardiovascular risk ( 31766143 ) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143 ) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009 ) Gut microbiota (functional units) ( 27694959 ) Hallux valgus ( 32131869 ) Height ( 28552196 25429064 20881960 31562340 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory skin disease ( 25574825 ) Menarche (age at onset) ( 25231870 ) Non-word reading ( 30741946 ) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 ) Treatment resistant depression ( 30468137 )	Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877 ) Mosquito bite size ( 28199695 ) Night sleep phenotypes ( 27126917 )
Novel Interactors		9 novel interactors: CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B RXRB SQSTM1	1 novel interactors: SLIT3
Interacting Genes		2 interacting genes: CAPN1 ROBO2	1 interacting genes: GPRASP2
Entrez ID		6586	3274
HPRD ID		04775	00816
Ensembl ID		ENSG00000184347	ENSG00000113749
Uniprot IDs		O75094	A0A1B0GTK7 P25021
PDB IDs		Not available	7UL3 8POK 8YN3 8YN4 8YUT
GO Terms Enriched among Interactors		None	Axon Extension Involved In Axon Guidance Response To Cortisol Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Roundabout Binding Roundabout Signaling Pathway Atrioventricular Valve Morphogenesis Hematopoietic Stem Cell Homeostasis Apoptotic Process Involved In Development Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Negative Chemotaxis Axon Extension Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Cardiac Septum Morphogenesis G Protein-coupled Receptor Binding