SLIT3

Name	slit guidance ligand 3
Structure	No pdb structure
Novel Interactors	9 novel interactors: CASP9 HRH2 IGSF8 KHDRBS3 MAML1 MAPK9 MGAT4B RXRB SQSTM1
Interactors	2 interactors: CAPN1 ROBO2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion
	Molecular Function	Calcium Ion Binding Heparin Binding Roundabout Binding
	Biological Process	Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Nervous System Development Axon Guidance Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Negative Regulation Of Gene Expression Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Cell Differentiation Negative Regulation Of Cell Growth Cellular Response To Hormone Stimulus Roundabout Signaling Pathway Axon Extension Involved In Axon Guidance Negative Chemotaxis Response To Cortisol Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
GWAS	Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 ) Bipolar disorder x sex interaction ( 34099189 ) Body mass index ( 31217584 ) Circulating leptin levels in high cardiovascular risk ( 31766143 ) Circulating leptin levels x sex interaction in high cardiovascular risk ( 31766143 ) Diastolic blood pressure x educational attainment (graduated college) interaction (2df) ( 32372009 ) Gut microbiota (functional units) ( 27694959 ) Hallux valgus ( 32131869 ) Height ( 28552196 25429064 20881960 31562340 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory skin disease ( 25574825 ) Menarche (age at onset) ( 25231870 ) Non-word reading ( 30741946 ) Total cholesterol levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429 ) Treatment resistant depression ( 30468137 )
Entrez ID	6586
HPRD ID	04775
Ensembl ID	ENSG00000184347
Uniprot IDs	O75094
PDB IDs	Not available