SLA and LAT

Number of citations of the paper that reports this interaction (PubMedID 10449770)
23

Data Source:
HPRD (in vivo)

		SLA	LAT
Description		Src like adaptor	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane COP9 Signalosome	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Membrane TCR Signalosome Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Molecular Condensate Scaffold Activity
	Biological Process	Signal Transduction Regulation Of MAPK Cascade	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Inflammatory Response Immune Response Signal Transduction Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Membrane Raft Distribution Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Negative regulation of FLT3	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 23612905) Multiple sclerosis ( 31604244) Temperament ( 22832960) Vitiligo ( 22561518 27723757)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		22 interacting genes: ABI2 BLK CBL CD247 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR1 FLT3 GAB1 GSK3B LAT MYO15B PAFAH1B2 PTK6 QARS1 SYK UBE4A VAV1 ZAP70	96 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FAM209A FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35H1 SLC51B SLC61A1 SLC71A2 SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		6503	27040
HPRD ID		03060	03832
Ensembl ID		ENSG00000155926	ENSG00000213658
Uniprot IDs		Q13239	O43561
PDB IDs		2CUD
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction ATP Binding Transferase Activity Positive Regulation Of MAPK Cascade Cell Migration Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway Cell Motility Nucleotide Binding Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Intracellular Signaling Cassette Protein Modification Process Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Growth Factor Binding Phosphotyrosine Residue Binding Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Developmental Process Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Protein Modification Process Plasma Membrane Cell Differentiation	Phosphotyrosine Residue Binding Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Plasma Membrane Immune Response-activating Signaling Pathway Cell-cell Junction Activation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Fc Receptor Signaling Pathway Lymphocyte Activation Leukocyte Activation Immune System Process Regulation Of Immune System Process Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Binding Signal Transduction Fc-gamma Receptor Signaling Pathway Cell Activation T Cell Activation Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Immune Effector Process B Cell Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Lymphocyte Differentiation T Cell Differentiation Positive Regulation Of Immune Effector Process Membrane Raft T Cell Receptor Complex Neurotrophin TRKA Receptor Binding Gamma-delta T Cell Activation Non-membrane Spanning Protein Tyrosine Kinase Activity Leukocyte Mediated Cytotoxicity Regulation Of Transport Lymphocyte Mediated Immunity T Cell Costimulation Adaptive Immune Response Leukocyte Differentiation Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Transport Mononuclear Cell Differentiation
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