SLA and UBE4A

Number of citations of the paper that reports this interaction (PMID 24457997)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SLA	UBE4A
Gene Name		Src-like-adaptor	ubiquitination factor E4A
Image
Gene Ontology Annotations	Cellular Component	Endosome	Ubiquitin Ligase Complex Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding Ligase Activity Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Positive Regulation Of Signal Transduction	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Graves' disease ( 23612905) Temperament ( 22832960) Vitiligo ( 22561518)	Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		14 interactors: CBL CD247 EGFR EPHA2 ERBB2 FGFR1 FLT3 GSK3B LAT PAFAH1B2 SYK UBE4A VAV1 ZAP70	11 interactors: CASP6 EPHA2 GZMB MAVS PTTG1 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		6503	9354
HPRD ID		03060	06793
Ensembl ID		ENSG00000155926	ENSG00000110344
Uniprot IDs		Q13239 Q6FI01	Q14139
PDB IDs		2CUD	1WGM
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Adhesion Response To Fibroblast Growth Factor Regulation Of Lymphocyte Activation Immune System Process Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Defense Response Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Signal Transduction Chemotaxis Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Migration Protein Phosphorylation Single Organismal Cell-cell Adhesion Cell Motility Beta Selection Positive Regulation Of Protein Serine/threonine Kinase Activity T Cell Aggregation	Protein K48-linked Ubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Polyubiquitination Positive Regulation Of Innate Immune Response Proteolysis Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Macromolecule Catabolic Process Cellular Response To Stress Apoptotic Process Immune Response-regulating Signaling Pathway Protein K11-linked Ubiquitination Programmed Cell Death Cell Death Death Protein Metabolic Process Positive Regulation Of Immune Response Immune Response Immune System Process Negative Regulation Of Type I Interferon Production Response To Stress Response To Hypoxia Innate Immune Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Positive Regulation Of IP-10 Production Notochord Cell Development Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination
Tagcloud ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Difference) ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	breakpoint causally complementary concordance dimerization disrupts ends facto frame fused hematopoeitic hematopoetic intrinsically investigators karyotype loc100131626 mdss mll reading rearrangement rearrangements shortly subclass tcf12 terminates transcripts transform uncommon unusual
Tagcloud (Intersection) ?