SLA and FLT3

Number of citations of the paper that reports this interaction (PMID 23300935)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SLA	FLT3
Gene Name		Src-like-adaptor	fms-related tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Endosome	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding
	Biological Process	Positive Regulation Of Signal Transduction	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation
Pathways
Drugs			Sorafenib Sunitinib Ponatinib
Diseases
GWAS		Graves' disease ( 23612905) Temperament ( 22832960) Vitiligo ( 22561518)
Protein-Protein Interactions		14 interactors: CBL CD247 EGFR EPHA2 ERBB2 FGFR1 FLT3 GSK3B LAT PAFAH1B2 SYK UBE4A VAV1 ZAP70	14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6
Entrez ID		6503	2322
HPRD ID		03060	00635
Ensembl ID		ENSG00000155926	ENSG00000122025
Uniprot IDs		Q13239 Q6FI01	P36888
PDB IDs		2CUD	1RJB 3QS7 3QS9
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Adhesion Response To Fibroblast Growth Factor Regulation Of Lymphocyte Activation Immune System Process Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Defense Response Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Signal Transduction Chemotaxis Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Migration Protein Phosphorylation Single Organismal Cell-cell Adhesion Cell Motility Beta Selection Positive Regulation Of Protein Serine/threonine Kinase Activity T Cell Aggregation	Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation
Tagcloud ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Difference) ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Intersection) ?