SLA and PAFAH1B2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SLA	PAFAH1B2
Gene Name		Src-like-adaptor	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
Image
Gene Ontology Annotations	Cellular Component	Endosome	Nucleolus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Positive Regulation Of Signal Transduction	Lipid Metabolic Process Spermatogenesis Brain Development Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways
Drugs
Diseases
GWAS		Graves' disease ( 23612905) Temperament ( 22832960) Vitiligo ( 22561518)	Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		14 interactors: CBL CD247 EGFR EPHA2 ERBB2 FGFR1 FLT3 GSK3B LAT PAFAH1B2 SYK UBE4A VAV1 ZAP70	14 interactors: ACIN1 ASF1A CCT3 PAFAH1B1 PAFAH1B3 PARK2 PINX1 PPP1R12C REXO1 RPLP0 SLA SNUPN TIMM50 ZFP36L1
Entrez ID		6503	5049
HPRD ID		03060	03940
Ensembl ID		ENSG00000155926	ENSG00000168092
Uniprot IDs		Q13239 Q6FI01	P68402
PDB IDs		2CUD	1VYH
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Innate Immune Response Regulation Of Immune Response Regulation Of Immune System Process Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Cell Adhesion Response To Fibroblast Growth Factor Regulation Of Lymphocyte Activation Immune System Process Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Defense Response Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Peptidyl-amino Acid Modification Regulation Of Signal Transduction Chemotaxis Regulation Of MAPK Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Migration Protein Phosphorylation Single Organismal Cell-cell Adhesion Cell Motility Beta Selection Positive Regulation Of Protein Serine/threonine Kinase Activity T Cell Aggregation	Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Protein Localization To Organelle Negative Regulation Of JNK Cascade MRNA Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway SnRNA Import Into Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Protein Localization To Mitochondrion Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Cellular Localization RNA Import Into Nucleus Positive Regulation Of Protein Linear Polyubiquitination Proepicardium Development Regulation Of Cytokine-mediated Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Targeting Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Dopamine Uptake Involved In Synaptic Transmission Establishment Of Centrosome Localization Adult Locomotory Behavior Catabolic Process Neuromuscular Process Cellular Component Assembly Protein Localization Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Chromosome Condensation Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Platelet Activating Factor Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Single Organism Reproductive Process Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of MAPK Cascade MRNA Catabolic Process Regulation Of JNK Cascade Adult Behavior Positive Regulation Of Monocyte Differentiation
Tagcloud ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Difference) ?		13s antimycin auranofin cdcl2 cddp dech dequalinium diamminedichloroplatinum diphenylphosphino diphenyltetrazolium dppe etbr ethane ethidium hela jam phosphine platinum rh123 rhodamine s1a s1b succinate tetraphenylphosphonium thenoyltrifluoroacetone tpp triphenyltetrazolium ttc ttfa	1b1 1b3 abpp acetylhydrolases adapted compound confirm determining discovered fluopol hydrolases ic50 impairs library nih noncatalytic p11 perturb polarization probes profiling reversible screen spermatogenesis supporting tetrahydropyridine
Tagcloud (Intersection) ?