SLA and PTK6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLA	PTK6
Description		Src like adaptor	protein tyrosine kinase 6
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane COP9 Signalosome	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Cell Projection
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding
	Biological Process	Signal Transduction Regulation Of MAPK Cascade	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		Negative regulation of FLT3	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs			Vandetanib Tivozanib Fostamatinib Zanubrutinib
Diseases
GWAS		Bone erosion in rheumatoid arthritis ( 28512992) Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 23612905) Multiple sclerosis ( 31604244) Temperament ( 22832960) Vitiligo ( 22561518 27723757)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		22 interacting genes: ABI2 BLK CBL CD247 EGFR EPHA2 ERBB2 ERBB3 ERBB4 FGFR1 FLT3 GAB1 GSK3B LAT MYO15B PAFAH1B2 PTK6 QARS1 SYK UBE4A VAV1 ZAP70	35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341
Entrez ID		6503	5753
HPRD ID		03060	03594
Ensembl ID		ENSG00000155926	ENSG00000101213
Uniprot IDs		Q13239	Q13882
PDB IDs		2CUD	1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4 8S1C
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphorylation Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling ERBB Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction ATP Binding Transferase Activity Positive Regulation Of MAPK Cascade Cell Migration Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway Cell Motility Nucleotide Binding Regulation Of Signal Transduction Signal Transduction Intracellular Signal Transduction Intracellular Signaling Cassette Protein Modification Process Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Modification Process Growth Factor Binding Phosphotyrosine Residue Binding Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Autophosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Developmental Process Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Protein Modification Process Plasma Membrane Cell Differentiation	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway SH2 Domain Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway ERBB3:ERBB2 Complex Visual Learning Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Visual Behavior Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Response To Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regulation Of DNA-templated Transcription Associative Learning Regulation Of RNA Biosynthetic Process Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?