CYTH1 and CYTIP

Number of citations of the paper that reports this interaction (PubMedID 12606567)
43

Data Source:
HPRD (two hybrid, in vitro)

		CYTH1	CYTIP
Description		cytohesin 1	cytohesin 1 interacting protein
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Membrane Anchoring Junction	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cell Cortex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	Protein Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Establishment Of Epithelial Cell Polarity	Regulation Of Cell Adhesion
Pathways		Intra-Golgi traffic
Drugs
Diseases
GWAS		Anxiety and major depressive disorder ( 24047446) Atrial fibrillation ( 30061737) HDL cholesterol levels ( 32203549) Pulse pressure ( 27841878 30578418) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878)	Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		13 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CYTIP FOSL2 GNAQ ITGB2 ITSN1 PCNT PRKCD SNAPC5 TRIM23	9 interacting genes: ARX CYTH1 CYTH2 CYTH3 KIF9 MCRS1 SCNM1 SHANK3 SOCS1
Entrez ID		9267	9595
HPRD ID		01630	09192
Ensembl ID		ENSG00000108669	ENSG00000115165
Uniprot IDs		B7Z9W0 K7ENQ8 Q15438	O60759
PDB IDs		1BC9 4A4P	2Z17
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Endomembrane System Nucleotide Binding Vesicle-mediated Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcomere Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Presynaptic Endocytosis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Erythrocyte Apoptotic Process Positive Regulation Of Protein Transport Fat Cell Apoptotic Process B Cell Proliferation Regulation Of Platelet Activation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Endosomal Transport Regulation Of Actin Filament Organization Intracellular Protein Localization Intracellular Transport GDP Binding Enzyme Activator Activity Regulation Of Biological Quality Cleavage Furrow Ingression Regulation Of Endocytosis Positive Regulation Of Secretion By Cell Protein Localization To Membrane G Protein Activity Lung Connective Tissue Development Alveolar Secondary Septum Development Regulation Of Body Fluid Levels Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Integrin AlphaL-beta2 Complex	Regulation Of ARF Protein Signal Transduction Bicellular Tight Junction Establishment Of Epithelial Cell Polarity Adherens Junction Guanyl-nucleotide Exchange Factor Activity Regulation Of Small GTPase Mediated Signal Transduction Lipid Binding Anchoring Junction Establishment Of Cell Polarity Guanylate Kinase-associated Protein Clustering Embryonic Olfactory Bulb Interneuron Precursor Migration
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