CYTH1 and ARF1

Number of citations of the paper that reports this interaction (PubMedID 9653114)
43

Data Source:
HPRD (in vitro)

		CYTH1	ARF1
Description		cytohesin 1	ARF GTPase 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Membrane Anchoring Junction	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endomembrane System Postsynaptic Density Membrane Sarcomere Cell Leading Edge Protein-containing Complex Neuron Projection Synapse Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Establishment Of Epithelial Cell Polarity	Regulation Of Receptor Internalization Intracellular Copper Ion Homeostasis Intracellular Protein Transport Protein Transport Vesicle-mediated Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Long-term Synaptic Depression Dendritic Spine Organization Cellular Response To Virus Mitotic Cleavage Furrow Ingression
Pathways		Intra-Golgi traffic	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Nef Mediated CD4 Down-regulation trans-Golgi Network Vesicle Budding MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Glycosphingolipid transport
Drugs			1,3-Propanediol Guanosine-3'-monophosphate-5'-diphosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Brefeldin A Myristic acid Chlortetracycline Glycerin
Diseases
GWAS		Anxiety and major depressive disorder ( 24047446) Atrial fibrillation ( 30061737) HDL cholesterol levels ( 32203549) Pulse pressure ( 27841878 30578418) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878)	Adolescent idiopathic scoliosis ( 31417091)
Interacting Genes		13 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CYTIP FOSL2 GNAQ ITGB2 ITSN1 PCNT PRKCD SNAPC5 TRIM23	50 interacting genes: AGAP1 AGAP2 AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 DENND1A DENND1B DUX4 EEF1G ERBB2 GGA1 GGA2 GGA3 GORAB GOSR2 HTR2A INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA SCYL1 SNCA TMED10 TMED2 TMEM106A WBP11
Entrez ID		9267	375
HPRD ID		01630	00054
Ensembl ID		ENSG00000108669	ENSG00000143761
Uniprot IDs		B7Z9W0 K7ENQ8 Q15438	P84077
PDB IDs		1BC9 4A4P	1HUR 1RE0 1U81 3O47 4HMY 6CM9 6CRI 6D83 6D84 6DFF 6FAE 7DN8 7DN9 7MGE 7R4H 7UX3 8D4C 8D4D 8D4E 8D4F 8D4G 8D9R 8D9S 8D9U 8D9W 8SDW 9C58 9C59 9C5A 9C5B
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Endomembrane System Nucleotide Binding Vesicle-mediated Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcomere Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Presynaptic Endocytosis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Erythrocyte Apoptotic Process Positive Regulation Of Protein Transport Fat Cell Apoptotic Process B Cell Proliferation Regulation Of Platelet Activation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Endosomal Transport Regulation Of Actin Filament Organization Intracellular Protein Localization Intracellular Transport GDP Binding Enzyme Activator Activity Regulation Of Biological Quality Cleavage Furrow Ingression Regulation Of Endocytosis Positive Regulation Of Secretion By Cell Protein Localization To Membrane G Protein Activity Lung Connective Tissue Development Alveolar Secondary Septum Development Regulation Of Body Fluid Levels Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Integrin AlphaL-beta2 Complex	Vesicle-mediated Transport Intracellular Protein Localization Golgi Apparatus Protein Transport Establishment Of Protein Localization Cellular Localization Intracellular Transport Establishment Of Localization In Cell Golgi Vesicle Transport Intracellular Protein Transport Membrane Coat Golgi Membrane Cytoplasmic Vesicle Membrane COPI-coated Vesicle Membrane Trans-Golgi Network Membrane Melanosome Assembly Localization Within Membrane Platelet Dense Granule Organization Post-Golgi Vesicle-mediated Transport Vesicle Cargo Loading COPI Vesicle Coat COPI-coated Vesicle Melanosome Organization Pigment Granule Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein Localization To Membrane Golgi To Vacuole Transport Early Endosome Transport Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Trans-Golgi Network Secretory Granule Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Localization To Cell Surface Intra-Golgi Vesicle-mediated Transport Organelle Organization Vesicle Organization Clathrin-coated Vesicle Membrane Synaptic Vesicle Transport Vesicle Coating AP-3 Adaptor Complex Protein Localization To Cell Periphery Endocytosis Clathrin Adaptor Complex Organelle Transport Along Microtubule Cytosol Synaptic Vesicle Budding From Endosome Vacuolar Transport
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