CYTH1 and ARFRP1

Number of citations of the paper that reports this interaction (PubMedID 10092663)
0

Data Source:
HPRD (two hybrid, in vitro)

		CYTH1	ARFRP1
Description		cytohesin 1	ARF related protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Membrane Anchoring Junction	Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Establishment Of Epithelial Cell Polarity	Intracellular Protein Transport Signal Transduction Gastrulation Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport
Pathways		Intra-Golgi traffic	Retrograde transport at the Trans-Golgi-Network Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Anxiety and major depressive disorder ( 24047446) Atrial fibrillation ( 30061737) HDL cholesterol levels ( 32203549) Pulse pressure ( 27841878 30578418) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 30604766) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Ulcerative colitis ( 28067908)
Interacting Genes		13 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CYTIP FOSL2 GNAQ ITGB2 ITSN1 PCNT PRKCD SNAPC5 TRIM23	6 interacting genes: AP1G1 AP1M1 CYTH1 GLP1R SMAD4 VANGL2
Entrez ID		9267	10139
HPRD ID		01630	05264
Ensembl ID		ENSG00000108669	ENSG00000101246
Uniprot IDs		B7Z9W0 K7ENQ8 Q15438	A0A384P5U7 B7ZKY8 Q13795
PDB IDs		1BC9 4A4P
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding Endomembrane System Nucleotide Binding Vesicle-mediated Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcomere Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Presynaptic Endocytosis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Erythrocyte Apoptotic Process Positive Regulation Of Protein Transport Fat Cell Apoptotic Process B Cell Proliferation Regulation Of Platelet Activation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Endosomal Transport Regulation Of Actin Filament Organization Intracellular Protein Localization Intracellular Transport GDP Binding Enzyme Activator Activity Regulation Of Biological Quality Cleavage Furrow Ingression Regulation Of Endocytosis Positive Regulation Of Secretion By Cell Protein Localization To Membrane G Protein Activity Lung Connective Tissue Development Alveolar Secondary Septum Development Regulation Of Body Fluid Levels Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Integrin AlphaL-beta2 Complex	Endosome To Melanosome Transport AP-1 Adaptor Complex Clathrin Adaptor Activity Melanosome Assembly Platelet Dense Granule Organization Clathrin-coated Vesicle Membrane Melanosome Organization Pigment Granule Organization Collagen Binding Clathrin-coated Vesicle Secretory Granule Organization Glucagon-like Peptide 1 Receptor Activity Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Synaptic Vesicle Budding From Endosome Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Establishment Of Planar Polarity Involved In Neural Tube Closure Cell Pole Cell Migration Involved In Kidney Development Lateral Sprouting Involved In Lung Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Trans-Golgi Network Membrane Intracellular Protein Transport Glucagon Receptor Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Serotonergic Neuron Axon Guidance Convergent Extension Involved In Neural Plate Elongation Dopaminergic Neuron Axon Guidance Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basolateral Protein Secretion Golgi Membrane Positive Regulation Of Natural Killer Cell Degranulation Cytoplasmic Vesicle Membrane Response To Psychosocial Stress Positive Regulation Of Luteinizing Hormone Secretion Anterior/posterior Pattern Specification Sulfate Binding Endocardial Cell Differentiation Establishment Or Maintenance Of Cell Polarity Apical Cytoplasm Convergent Extension Involved In Organogenesis Establishment Of Body Hair Planar Orientation Establishment Of Planar Polarity Of Embryonic Epithelium Axonemal Central Apparatus Assembly
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