CYTH1 and ARFRP1

Number of citations of the paper that reports this interaction (PMID 10092663)
5

Data Source:
HPRD (in vitro, two hybrid)

		CYTH1	ARFRP1
Gene Name		cytohesin 1	ADP-ribosylation factor related protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Tight Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Golgi Apparatus Trans-Golgi Network Membrane
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Epithelial Cell Polarity	Signal Transduction Small GTPase Mediated Signal Transduction Gastrulation Metabolic Process Protein Localization To Golgi Apparatus Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		12 interactors: ACTA1 ARF1 ARF6 ARFRP1 ARR3 CYTIP GNAQ IPCEF1 ITGB2 ITSN1 PRKCD TRIM23	3 interactors: CYTH1 GLP1R SMAD4
Entrez ID		9267	10139
HPRD ID		01630	05264
Ensembl ID		ENSG00000108669	ENSG00000101246
Uniprot IDs		Q15438	B7ZKY8 Q13795
PDB IDs		1BC9 4A4P
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Signal Transduction Intracellular Signal Transduction Signaling Regulation Of Filopodium Assembly Regulation Of Phosphorylation Cell Communication Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Lipase Activity Regulation Of Actin Filament-based Process Protein Stabilization Positive Regulation Of Phospholipid Catabolic Process Skeletal Muscle Fiber Adaptation Apoptotic Process Blood Coagulation Hemostasis Programmed Cell Death Lymphocyte Proliferation Cell Death Mononuclear Cell Proliferation Death Regulation Of Protein Phosphorylation Interleukin-10 Production Regulation Of Cell Projection Assembly Leukocyte Proliferation Regulation Of Cytoskeleton Organization Negative Regulation Of Filopodium Assembly Regulation Of Protein Stability Interleukin-12 Production Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Ceramide Biosynthetic Process Wound Healing Skeletal Muscle Thin Filament Assembly Regulation Of Actin Filament Polymerization Embryonic Morphogenesis Endocytosis	Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nephrogenic Mesenchyme Morphogenesis Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Endocardial Cell Differentiation Formation Of Anatomical Boundary Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Brainstem Development SMAD Protein Complex Assembly Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Heart Valve Formation Metanephric Mesenchyme Development Endocardial Cushion Formation Endocardium Development Establishment Of Epithelial Cell Polarity Regulation Of Protein Transport Atrioventricular Valve Morphogenesis Regulation Of Signaling Regulation Of Hair Cycle Regulation Of Establishment Of Protein Localization Endocardial Cushion Morphogenesis Atrioventricular Valve Development CAMP-mediated Signaling Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Heart Morphogenesis Activation Of Adenylate Cyclase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Heart Valve Morphogenesis Cyclic-nucleotide-mediated Signaling Heart Valve Development Endocardial Cushion Development Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of BMP Signaling Pathway Cellular Response To Glucagon Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Lyase Activity Embryonic Axis Specification
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