SPPL2A

Description		signal peptide peptidase like 2A
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Late Endosome Membrane Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane Cytoplasmic Side Of Endoplasmic Reticulum Membrane Bounding Membrane Of Organelle
	Molecular Function	Protein Binding Peptidase Activity Hydrolase Activity Aspartic Endopeptidase Activity, Intramembrane Cleaving Protein Homodimerization Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Membrane Protein Proteolysis Regulation Of Immune Response
Pathways		Regulation of TNFR1 signaling
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 24162737 30820047) Calcium levels ( 29403010) Chloride levels ( 29403010) Creatinine levels ( 29403010) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) General cognitive ability ( 29844566) Glomerular filtration rate ( 29403010) Lymphocyte count ( 32888494) Neutrophil count ( 27863252 32888494) Potassium levels ( 29403010) Red blood cell count ( 32888494) Refractive error ( 32231278) Sum basophil neutrophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: NFKB1 SGTA
Entrez ID		84888
HPRD ID		09742
Ensembl ID		ENSG00000138600
Uniprot IDs		A0A8V8TLZ2 Q8TCT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Nicotine Cellular Response To Interleukin-17 Mammary Gland Involution Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Hyaluronan Biosynthetic Process NF-kappaB P50/p65 Complex Positive Regulation Of Hyaluronan Biosynthetic Process I-kappaB/NF-kappaB Complex TRC Complex BAT3 Complex Binding Negative Regulation Of ERAD Pathway Regulation Of Vitamin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Cellular Response To Angiotensin Actinin Binding Cellular Response To Interleukin-6 Antibacterial Innate Immune Response Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To DsRNA Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Positive Regulation Of Lipid Storage Positive Regulation Of ERAD Pathway Negative Regulation Of Steroid Biosynthetic Process Response To Angiotensin Regulation Of ERAD Pathway Response To Muscle Stretch Positive Regulation Of Cholesterol Efflux Negative Regulation Of Steroid Metabolic Process Protein Targeting To ER Protein Insertion Into ER Membrane Regulation Of Macrophage Derived Foam Cell Differentiation Non-canonical NF-kappaB Signal Transduction Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Cholesterol Transport Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To Nicotine Response To DsRNA Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Response To Endoplasmic Reticulum Stress Transcription Coactivator Binding Specific Granule Lumen Positive Regulation Of Transcription Initiation By RNA Polymerase II Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process
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