SPPL2A

Gene Name		signal peptide peptidase like 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Golgi-associated Vesicle Membrane Late Endosome Membrane Extracellular Vesicular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Membrane Protein Ectodomain Proteolysis Membrane Protein Intracellular Domain Proteolysis Regulation Of Immune Response
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: NFKB1 SGTA
Entrez ID		84888
HPRD ID		09742
Ensembl ID		ENSG00000138600
Uniprot IDs		Q8TCT8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Cellular Response To Nicotine Regulation Of Calcidiol 1-monooxygenase Activity Regulation Of MiRNA Metabolic Process Negative Regulation Of Cholesterol Transport Negative Regulation Of Monooxygenase Activity Regulation Of Vitamin Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Interleukin-12 Production Response To Copper Ion Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Lipid Transport Negative Regulation Of Steroid Metabolic Process Negative Regulation Of Oxidoreductase Activity Cellular Response To Interleukin-6 Positive Regulation Of Macrophage Derived Foam Cell Differentiation Response To Interleukin-6 Positive Regulation Of Lipid Storage Membrane Protein Proteolysis Negative Regulation Of Cytokine Biosynthetic Process Regulation Of Cholesterol Transport Response To Nicotine Cellular Response To Alkaloid NIK/NF-kappaB Signaling Negative Regulation Of Lipid Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lipid Storage Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Interleukin-12 Production MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Steroid Biosynthetic Process Cellular Response To Mechanical Stimulus Regulation Of Oxidoreductase Activity Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Type I Interferon Production
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