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AKTIP and PDPK1
Number of citations of the paper that reports this interaction (PubMedID
14749367
)
52
Data Source:
HPRD
(in vivo)
AKTIP
PDPK1
Description
AKT interacting protein
3-phosphoinositide dependent protein kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Membrane
HOPS Complex
FHF Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Anchoring Junction
Molecular Function
Protein Binding
Ubiquitin-like Protein Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Phospholipase Activator Activity
Kinase Activity
Transferase Activity
Phospholipase Binding
Protein Serine Kinase Activity
Biological Process
Positive Regulation Of Protein Phosphorylation
Postreplication Repair
Apoptotic Process
Endosome Organization
Lysosome Organization
Endosome To Lysosome Transport
Protein Transport
Positive Regulation Of Protein Binding
Early Endosome To Late Endosome Transport
Protein K63-linked Ubiquitination
Protein Localization To Perinuclear Region Of Cytoplasm
Type B Pancreatic Cell Development
Protein Phosphorylation
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Endothelial Cell Migration
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Mast Cell Degranulation
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Intracellular Signaling Cassette
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Diseases
GWAS
Body mass index (
26426971
)
Body mass index (age>50) (
26426971
)
Body mass index x sex x age interaction (4df test) (
26426971
)
Depressive symptoms (SSRI exposure interaction) (
25649181
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Hip circumference adjusted for BMI (
25673412
34021172
)
Serum alkaline phosphatase levels (
33547301
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Hip circumference adjusted for BMI (
34021172
)
Interacting Genes
35 interacting genes:
ACTN2
AKT1
ASS1
CEP126
CTBP2
DMXL2
DZIP3
EXOC7
FHIP1B
GTF3C1
HOOK1
HOOK2
HOOK3
IMMT
IPO7
LMNA
MAP3K7
MARCHF5
MATR3
NEB
PDE4DIP
PDPK1
POLA2
RASGRF2
RPA1
TRIM23
TRIM41
TWNK
UPF2
UTP14A
VPS16
VPS18
VPS28
VPS41
ZNRF2
68 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
CSNK1D
CUL3
DDIT4
GIT1
GSK3B
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
KLHL20
LUC7L2
MAPK8
MTOR
NHERF2
PAK1
PEA15
PHAX
PIK3C3
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SMARCB1
SOCS3
SPOP
SRC
SRPK1
STRAP
TCAP
UBC
UBE2I
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
64400
5170
HPRD ID
07467
05556
Ensembl ID
ENSG00000166971
ENSG00000140992
Uniprot IDs
Q9H8T0
E9PER6
O15530
PDB IDs
8QAT
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
6WJQ
8DQT
Enriched GO Terms of Interacting Partners
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HOPS Complex
Endosome To Lysosome Transport
FHF Complex
Intracellular Protein Localization
Protein Transport
Vacuolar Transport
Protein Localization To Perinuclear Region Of Cytoplasm
Intracellular Transport
Lysosomal Transport
Establishment Of Protein Localization
Cellular Localization
Endosome Organization
Intracellular Protein Transport
Establishment Of Localization In Cell
Early Endosome To Late Endosome Transport
Vesicle Organization
Lysosome Organization
Cytoplasmic Microtubule Organization
Vacuole Organization
Regulation Of SNARE Complex Assembly
Endosomal Vesicle Fusion
Protein Localization To Organelle
Identical Protein Binding
Cellular Response To Laminar Fluid Shear Stress
Organelle Organization
Response To Laminar Fluid Shear Stress
Vesicle-mediated Transport
Endosomal Transport
Endosome Membrane
Dynein Light Intermediate Chain Binding
CGAS/STING Signaling Pathway
Membrane Organization
Cellular Response To Fluid Shear Stress
Establishment Of Protein Localization To Organelle
Ubiquitin Protein Ligase Activity
CORVET Complex
Response To Fluid Shear Stress
Protein Import Into Nucleus
Positive Regulation Of CGAS/STING Signaling Pathway
Import Into Nucleus
Vascular Endothelial Cell Response To Laminar Fluid Shear Stress
Nuclear Transport
Nucleocytoplasmic Transport
Protein Ubiquitination
AP-3 Adaptor Complex
Positive Regulation Of Pattern Recognition Receptor Signaling Pathway
Regulation Of Innate Immune Response
Anoikis
Microtubule Cytoskeleton Organization
Late Endosome Membrane
Protein Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Kinase Activity
Protein Phosphorylation
Phosphorylation
Intracellular Signal Transduction
ATP Binding
Protein Modification Process
Cytosol
Cellular Response To Peptide Hormone Stimulus
Nucleotide Binding
Cellular Response To Oxygen-containing Compound
Protein Metabolic Process
Cellular Response To Hormone Stimulus
Cytoplasm
Diacylglycerol-dependent Serine/threonine Kinase Activity
Regulation Of Cellular Response To Insulin Stimulus
Nucleus
TOR Signaling
Transferase Activity
TORC1 Signaling
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Response To Peptide Hormone
Negative Regulation Of Cellular Response To Insulin Stimulus
Response To Hormone
Phosphate-containing Compound Metabolic Process
Signal Transduction
Regulation Of Signal Transduction
Negative Regulation Of TOR Signaling
Regulation Of Generation Of Precursor Metabolites And Energy
Cellular Response To Insulin Stimulus
Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Regulation Of TOR Signaling
Regulation Of Signaling
Negative Regulation Of Apoptotic Process
Regulation Of Cell Communication
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Programmed Cell Death
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Signal Transduction
Cellular Response To Fluid Shear Stress
Regulation Of Apoptotic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Signal Transduction
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Tagcloud (Difference)
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Tagcloud (Intersection)
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