AKTIP and UPF2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		AKTIP	UPF2
Description		AKT interacting protein	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Diverticular disease ( 30177863)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		64400	26019
HPRD ID		07467	10405
Ensembl ID		ENSG00000166971	ENSG00000151461
Uniprot IDs		Q9H8T0	Q9HAU5
PDB IDs		8QAT	1UW4 2WJV 4CEK 4CEM 7NWU 7QG6
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane	RNA Binding Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process RRNA Metabolic Process RRNA Processing Nucleic Acid Metabolic Process Exosome (RNase Complex) Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Metabolic Process Histone MRNA Catabolic Process Nuclear Exosome (RNase Complex) Negative Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleolar Exosome (RNase Complex) Negative Regulation Of Macromolecule Biosynthetic Process Nuclear MRNA Surveillance Ribosome Histone MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Processing Ribosomal Small Subunit Biogenesis Translation Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleolus Nucleic Acid Binding Cytosolic Ribosome Positive Regulation Of MRNA Cis Splicing, Via Spliceosome 5'-3' RNA Exonuclease Activity Regulation Of Metabolic Process Nuclear RNA Surveillance RRNA Catabolic Process RNA Surveillance DNA Metabolic Process Cytosol Cytoplasmic Translation Negative Regulation Of Protein Metabolic Process Macromolecule Catabolic Process
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