AKTIP and FHIP1B

Number of citations of the paper that reports this interaction (PubMedID 34882091)
68

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo)

		AKTIP	FHIP1B
Description		AKT interacting protein	FHF complex subunit HOOK interacting protein 1B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex	FHF Complex
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2	9 interacting genes: AGTRAP AKTIP HOOK1 HOOK2 RAB5B RABAC1 REEP6 RTN1 RTN3
Entrez ID		64400	84067
HPRD ID		07467	08002
Ensembl ID		ENSG00000166971	ENSG00000051009
Uniprot IDs		Q9H8T0	Q8N612
PDB IDs		8QAT	8QAT
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane	FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm HOPS Complex Endosome Organization Early Endosome To Late Endosome Transport Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Formation Lysosome Organization Endosome To Lysosome Transport Endosomal Transport Endoplasmic Reticulum Tubular Network Membrane Organization Vesicle Organization Endoplasmic Reticulum Membrane Organization Lysosomal Transport Organelle Organization Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Amyloid-beta Formation Vacuolar Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Vacuole Organization Dynein Light Intermediate Chain Binding Vesicle-mediated Transport Regulation Of Amyloid-beta Formation Golgi Apparatus Regulation Of Amyloid Precursor Protein Catabolic Process Cytoplasmic Microtubule Organization Regulation Of Amide Metabolic Process Endoplasmic Reticulum Membrane Protein Transport Intracellular Transport Angiotensin Type II Receptor Activity Establishment Of Protein Localization Golgi Membrane Manchette Assembly Cytoskeleton-dependent Intracellular Transport Cellular Localization Plasma Membrane To Endosome Transport Endoplasmic Reticulum Positive Regulation Of Protein Binding Establishment Of Localization In Cell Brain Development Postsynaptic Density Microtubule Binding Cytoplasmic Vesicle Intracellular Protein Localization Identical Protein Binding Proline-rich Region Binding Ubiquitin-like Protein Transferase Activity GTP-dependent Protein Binding Angiotensin-activated Signaling Pathway
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