AKTIP and RASGRF2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		AKTIP	RASGRF2
Description		AKT interacting protein	Ras protein specific guanine nucleotide releasing factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Response To Endoplasmic Reticulum Stress Regulation Of Small GTPase Mediated Signal Transduction Long-term Synaptic Potentiation Postsynaptic Modulation Of Chemical Synaptic Transmission
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Adventurousness ( 30643258) Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 28869591 30598549) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Orofacial clefts ( 22419666) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Statin-induced myopathy (severe) ( 31220337) Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2	5 interacting genes: AKTIP CDC42 KRAS RAC1 RHOA
Entrez ID		64400	5924
HPRD ID		07467	07588
Ensembl ID		ENSG00000166971	ENSG00000113319
Uniprot IDs		Q9H8T0	A0A2X0SFL3 O14827
PDB IDs		8QAT
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane	G Protein Activity Wnt Signaling Pathway, Planar Cell Polarity Pathway Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Membrane Invagination Non-canonical Wnt Signaling Pathway Positive Regulation Of Actin Filament Bundle Assembly GTPase Activity GTP Binding Actin Cytoskeleton Organization Actin Filament-based Process G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Stress Fiber Assembly Focal Adhesion Thioesterase Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Establishment Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Postsynapse Positive Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Intracellular Signaling Cassette Establishment Of Epithelial Cell Polarity Phagocytosis, Engulfment Positive Regulation Of Phosphorylation Actin Filament Organization Regulation Of Actin Filament Organization Wnt Signaling Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Cytoskeleton Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Semaphorin-plexin Signaling Pathway Positive Regulation Of Cytokinesis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Substantia Nigra Development Endoplasmic Reticulum Membrane
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