AKTIP and IPO7

Number of citations of the paper that reports this interaction (PubMedID 27512140)
51

Data Source:
BioGRID (pull down)

		AKTIP	IPO7
Description		AKT interacting protein	importin 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Innate Immune Response Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Odontoblast Differentiation
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Interleukin-10 levels ( 22205395)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2	14 interacting genes: AKTIP CEBPA H1-0 KPNB1 LIMS1 LINC01554 NOSIP PTEN RAN RNF10 RPL23A RPL5 RPS7 SRP19
Entrez ID		64400	10527
HPRD ID		07467	09280
Ensembl ID		ENSG00000166971	ENSG00000205339
Uniprot IDs		Q9H8T0	B3KNG9 O95373
PDB IDs		8QAT
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane	Cytosolic Ribosome RNA Import Into Nucleus RNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Importin-alpha Family Protein Binding Negative Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Cytoplasmic Translation Regulation Of Proteolysis MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Ribonucleoprotein Complex Structural Constituent Of Ribosome Protein-containing Complex Nucleus Spindle Organization Negative Regulation Of Catalytic Activity Ribosome RRNA Binding Positive Regulation Of Binding Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Catalytic Activity Protein Stabilization Cytosolic Large Ribosomal Subunit Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Cell Development Response To Vitamin B2 C/EBP Complex Regulation Of Focal Adhesion Assembly Regulation Of Protein Modification Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Cell-substrate Junction Organization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding CHOP-C/EBP Complex
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