AKTIP and DMXL2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		AKTIP	DMXL2
Description		AKT interacting protein	Dmx like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex	Extracellular Space Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle RAVE Complex Synapse Neuronal Dense Core Vesicle
	Molecular Function	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity	Small GTPase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Vacuolar Acidification
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) C-reactive protein levels ( 30388399) Intelligence (MTAG) ( 29326435) Triglyceride levels ( 32203549)
Interacting Genes		35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2	5 interacting genes: AKTIP ETS2 MTNR1B PCNT RAB3A
Entrez ID		64400	23312
HPRD ID		07467	10188
Ensembl ID		ENSG00000166971	ENSG00000104093
Uniprot IDs		Q9H8T0	H0YLM8 Q8TDJ6
PDB IDs		8QAT
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane	Ectodermal Cell Fate Commitment Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Constitutive Secretory Pathway Synaptic Vesicle Maturation Regulation Of Presynaptic Dense Core Granule Exocytosis Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Regulation Of Plasma Membrane Repair Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Acrosomal Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Dense Core Granule Exocytosis Evoked Neurotransmitter Secretion Maintenance Of Presynaptic Active Zone Structure Clathrin-sculpted Monoamine Transport Vesicle Membrane Sensory Perception Of Touch FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Primitive Streak Formation Cell Fate Commitment Involved In Formation Of Primary Germ Layer Nuclear Glucocorticoid Receptor Binding Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Vesicle Organization Synaptic Vesicle Clustering Regulation Of Short-term Neuronal Synaptic Plasticity Presynaptic Active Zone Organization Positive Regulation Of Protein Binding HOPS Complex Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Plasma Membrane Organization Myosin V Binding Synaptic Vesicle Recycling Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Nervous System Process Regulation Of Circadian Sleep/wake Cycle, Sleep Ubiquitin-like Protein Transferase Activity Positive Regulation Of Circadian Rhythm Regulation Of Protein Transport GTP-dependent Protein Binding
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