GMCL1 and PBXIP1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GMCL1	PBXIP1
Description		germ cell-less 1, spermatogenesis associated	PBX homeobox interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Cytoskeleton Microtubule
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Germ Cell Development Spermatogenesis Cell Differentiation	Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of DNA-templated Transcription Cell Adhesion Gene Expression Cell Migration Extracellular Matrix Disassembly Hemopoiesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Articular Cartilage Development Gene Expression Involved In Extracellular Matrix Organization Positive Regulation Of Chondrocyte Proliferation
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250	27 interacting genes: BRPF1 CAMLG CAPN2 CCDC85B DAXX DEF6 DPPA2 DSCR9 ESR1 GABARAPL1 GMCL1 GRB2 KRTAP10-6 LCA5L MDFI MDM2 MORF4L1 PCBD2 PPTC7 PRKAA2 SGTA TSNAX UBQLN1 UBQLN4 WASHC3 ZMYND8 ZZZ3
Entrez ID		64395	57326
HPRD ID		13587	17823
Ensembl ID		ENSG00000087338	ENSG00000163346
Uniprot IDs		Q53SE7 Q96IK5	B4E0K4 Q96AQ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process	Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Autophagy Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Metabolic Process Nucleus Chromatin Organization Cellular Response To Estrogen Stimulus Positive Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of ERAD Pathway Autophagosome Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Protein Insertion Into ER Membrane
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