GMCL1 and APLF

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GMCL1	APLF
Gene Name		germ cell-less, spermatogenesis associated 1	aprataxin and PNKP like factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Matrix	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function		Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Cell Differentiation	Single Strand Break Repair DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Cellular Response To DNA Damage Stimulus Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: APLF APOL6 BYSL C21orf2 C5orf60 CCDC25 CHIC2 CIB3 CLK2 CUL3 EMD FAM167A FAM63A FKBP1B FOSL2 FOXR1 FRMD6 GAGE1 GAGE12B GAGE12I GAGE2E GAGE5 GLRX3 GMCL1P1 GRAMD1A HYKK IL17F KAT5 KIFC3 KPNA2 MID1 MID2 MORF4L1 MPPE1 MTRR NEBL NUMA1 PARD6B PARP16 PAX4 PBXIP1 PTPN7 QRICH1 RAD54B SHQ1 SLC15A3 SNX20 STK3 SUMO1 SUMO1P1 SYT17 TCEB3 TMPO TRIM13 TRIM38 TRIM54 TSG101 TSSC4 XAGE2 XAGE3 ZNF250	9 interactors: APP FBXO25 GMCL1 IRX5 LIG4 PARP1 XRCC1 XRCC4 XRCC5
Entrez ID		64395	200558
HPRD ID		13587	09848
Ensembl ID			ENSG00000169621
Uniprot IDs		Q53SE7 Q96IK5	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Double-strand Break Repair Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Viral Release From Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Axon Regeneration Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Transcription Protein Localization To Cytoskeleton Regulation Of Viral Release From Host Cell DNA Metabolic Process Cellular Protein Modification Process DNA Repair Trophectodermal Cell Differentiation Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Nucleus Organization Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Localization Negative Regulation Of Microtubule Depolymerization Cardiac Muscle Thin Filament Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Blastocyst Formation Response To Ionizing Radiation Modification-dependent Protein Catabolic Process Cellular Response To Interferon-gamma	Establishment Of Integrated Proviral Latency Establishment Of Viral Latency Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Double-strand Break Repair DNA Repair Pro-B Cell Differentiation Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Cellular Response To DNA Damage Stimulus Lymphoid Progenitor Cell Differentiation DNA Ligation Response To Radiation Response To Ionizing Radiation Cellular Response To Lithium Ion DNA Metabolic Process Single Strand Break Repair Hematopoietic Progenitor Cell Differentiation Cell Differentiation Isotype Switching V(D)J Recombination Hemopoiesis Neuron Maturation Response To Lithium Ion DNA Recombination Somatic Recombination Of Immunoglobulin Gene Segments Immune System Development Regulation Of Neurogenesis Somatic Diversification Of Immunoglobulins Cellular Response To Stress Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Generation Of Neurons B Cell Activation Involved In Immune Response Neurogenesis Response To Gamma Radiation Regulation Of Cell Development Neuron Apoptotic Process Leukocyte Differentiation Organ Development Immunoglobulin Production Nucleobase-containing Compound Metabolic Process Base-excision Repair Positive Regulation Of Fibroblast Proliferation Neuron Death T Cell Differentiation In Thymus Central Nervous System Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Telomere Maintenance
Tagcloud ?		asm atm bouquet compensate conjugating dmc1 doubling dsbs gadd45a haploid hop2 hr6b insignificant joining ku80 m1jcs mei1 meiosis mlh1 pairing preleptotene prophase segregates spermatocytes spermatogenesis spermiogenesis spo11 terf1 tnp1	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Difference) ?		asm atm bouquet compensate conjugating dmc1 doubling dsbs gadd45a haploid hop2 hr6b insignificant joining ku80 m1jcs mei1 meiosis mlh1 pairing preleptotene prophase segregates spermatocytes spermatogenesis spermiogenesis spo11 terf1 tnp1	acidic adp analogs ation binds chaperone chaperones chromatin collectively define eukaryotes exhibits h4 histone histones homologous localize modulates motif nap1l poly poorly preferentially reactions relaxation repair ribose ribosyl tetramer
Tagcloud (Intersection) ?