GMCL1 and APOL6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GMCL1	APOL6
Description		germ cell-less 1, spermatogenesis associated	apolipoprotein L6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Extracellular Region Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Lipid Binding
	Biological Process	Germ Cell Development Spermatogenesis Cell Differentiation	Lipid Transport Lipoprotein Metabolic Process
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)	HDL cholesterol levels ( 32203549) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250	10 interacting genes: ADAMTSL4 CCN3 FNTB GMCL1 KPNA3 KRTAP10-8 LAMTOR3 MTNR1B RGS13 TEPSIN
Entrez ID		64395	80830
HPRD ID		13587	06266
Ensembl ID		ENSG00000087338	ENSG00000221963
Uniprot IDs		Q53SE7 Q96IK5	B3KTP4 Q9BWW8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process	Negative Regulation Of Nervous System Process Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Pigment Cell Development Coated Vesicle Membrane Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Protein Farnesyltransferase Complex Protein Farnesyltransferase Activity Protein Prenyltransferase Activity Protein Farnesylation Viral Penetration Into Host Nucleus Melatonin Receptor Activity Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Transport Regulation Of Nervous System Process Regulation Of Neuronal Action Potential Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Endothelial Cell-cell Adhesion Bone Regeneration Ragulator Complex Intracellular Transport Of Virus Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Secretion By Cell Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Monocyte Chemotaxis Smooth Muscle Cell Proliferation FNIP-folliculin RagC/D GAP Interstitial Matrix Protein Prenylation Host Cell Prenyltransferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Peptide Hormone Secretion Acetyltransferase Activator Activity Endothelial Cell Chemotaxis
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