GMCL1 and STK3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GMCL1	STK3
Gene Name		germ cell-less, spermatogenesis associated 1	serine/threonine kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Matrix	Nucleus Cytoplasm Cytosol
	Molecular Function		Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Cell Differentiation	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		61 interactors: APLF APOL6 BYSL C21orf2 C5orf60 CCDC25 CHIC2 CIB3 CLK2 CUL3 EMD FAM167A FAM63A FKBP1B FOSL2 FOXR1 FRMD6 GAGE1 GAGE12B GAGE12I GAGE2E GAGE5 GLRX3 GMCL1P1 GRAMD1A HYKK IL17F KAT5 KIFC3 KPNA2 MID1 MID2 MORF4L1 MPPE1 MTRR NEBL NUMA1 PARD6B PARP16 PAX4 PBXIP1 PTPN7 QRICH1 RAD54B SHQ1 SLC15A3 SNX20 STK3 SUMO1 SUMO1P1 SYT17 TCEB3 TMPO TRIM13 TRIM38 TRIM54 TSG101 TSSC4 XAGE2 XAGE3 ZNF250	33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		64395	6788
HPRD ID		13587	05433
Ensembl ID			ENSG00000104375
Uniprot IDs		Q53SE7 Q96IK5	B3KYA7 Q13188
PDB IDs			4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Protein Localization To Microtubule Double-strand Break Repair Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Viral Transcription Negative Regulation Of Viral Release From Host Cell Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Axon Regeneration Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Transcription Protein Localization To Cytoskeleton Regulation Of Viral Release From Host Cell DNA Metabolic Process Cellular Protein Modification Process DNA Repair Trophectodermal Cell Differentiation Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Nucleus Organization Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Cellular Localization Negative Regulation Of Microtubule Depolymerization Cardiac Muscle Thin Filament Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Blastocyst Formation Response To Ionizing Radiation Modification-dependent Protein Catabolic Process Cellular Response To Interferon-gamma	Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?		asm atm bouquet compensate conjugating dmc1 doubling dsbs gadd45a haploid hop2 hr6b insignificant joining ku80 m1jcs mei1 meiosis mlh1 pairing preleptotene prophase segregates spermatocytes spermatogenesis spermiogenesis spo11 terf1 tnp1	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		asm atm bouquet compensate conjugating dmc1 doubling dsbs gadd45a haploid hop2 hr6b insignificant joining ku80 m1jcs mei1 meiosis mlh1 pairing preleptotene prophase segregates spermatocytes spermatogenesis spermiogenesis spo11 terf1 tnp1	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?