GMCL1 and PARP16

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GMCL1	PARP16
Description		germ cell-less 1, spermatogenesis associated	poly(ADP-ribose) polymerase family member 16
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Identical Protein Binding	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Kinase Binding Protein Serine/threonine Kinase Activator Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Germ Cell Development Spermatogenesis Cell Differentiation	Cytoplasmic Translation Response To Unfolded Protein Viral Protein Processing Endoplasmic Reticulum Unfolded Protein Response NAD+ Biosynthetic Process Via The Salvage Pathway IRE1-mediated Unfolded Protein Response Protein Auto-ADP-ribosylation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Cytoplasmic Translation
Pathways			Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)
Interacting Genes		98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250	2 interacting genes: GMCL1 NEDD4
Entrez ID		64395	54956
HPRD ID		13587	07919
Ensembl ID		ENSG00000087338	ENSG00000138617
Uniprot IDs		Q53SE7 Q96IK5	Q8N5Y8
PDB IDs			4F0D 6HXR 6HXS 6W65
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process	Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Negative Regulation Of Potassium Ion Transmembrane Transport Apicolateral Plasma Membrane Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Viral Budding Negative Regulation Of Potassium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuromuscular Junction Development
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