PBXIP1 and BRPF1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PBXIP1	BRPF1
Description		PBX homeobox interacting protein 1	bromodomain and PHD finger containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Cytoskeleton Microtubule	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Plasma Membrane MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding DNA-binding Transcription Factor Binding	DNA Binding Protein Binding Zinc Ion Binding Acetyltransferase Activator Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of DNA-templated Transcription Cell Adhesion Gene Expression Cell Migration Extracellular Matrix Disassembly Hemopoiesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Articular Cartilage Development Gene Expression Involved In Extracellular Matrix Organization Positive Regulation Of Chondrocyte Proliferation	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of Developmental Process Regulation Of Hemopoiesis
Pathways			HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)
Interacting Genes		27 interacting genes: BRPF1 CAMLG CAPN2 CCDC85B DAXX DEF6 DPPA2 DSCR9 ESR1 GABARAPL1 GMCL1 GRB2 KRTAP10-6 LCA5L MDFI MDM2 MORF4L1 PCBD2 PPTC7 PRKAA2 SGTA TSNAX UBQLN1 UBQLN4 WASHC3 ZMYND8 ZZZ3	12 interacting genes: CDCA7L CEP63 CEP70 GTF2H1 H3C14 KIAA0753 NECAB1 NFE2L2 PBXIP1 USHBP1 USP20 USP7
Entrez ID		57326	7862
HPRD ID		17823	03875
Ensembl ID		ENSG00000163346	ENSG00000156983
Uniprot IDs		B4E0K4 Q96AQ6	A0A804HI52 A0A804HIN1 A0A804HKY8 A0A804HL48 A0A8C8KWW5 P55201
PDB IDs			2D9E 2RS9 2X35 2X4W 2X4X 2X4Y 3L42 3MO8 4LC2 4QYD 4QYL 4UYE 5C6S 5C7N 5C85 5C87 5C89 5D7X 5DY7 5DYA 5DYC 5E3D 5E3G 5EM3 5EPR 5EPS 5EQ1 5ERC 5ETB 5ETD 5EV9 5EVA 5EWC 5EWD 5EWH 5EWV 5EWW 5FFV 5FFW 5FFY 5FG4 5FG5 5G4R 5G4S 5MWG 5MWH 5MWZ 5MYG 5O4S 5O4T 5O55 5O5A 5O5F 5O5H 5OV8 5OWA 5OWB 5OWE 5T4U 5T4V 6EKQ 6U04 7C4I 8QAZ 8QB0 8QB2
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Autophagy Regulation Of Primary Metabolic Process Regulation Of Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Metabolic Process Nucleus Chromatin Organization Cellular Response To Estrogen Stimulus Positive Regulation Of Proteolysis Regulation Of Macroautophagy Positive Regulation Of ERAD Pathway Autophagosome Regulation Of Macromolecule Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Protein Insertion Into ER Membrane	Centrosome Centriole Replication Centriole Assembly
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