GMCL1 and PTPN7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GMCL1	PTPN7
Description		germ cell-less 1, spermatogenesis associated	protein tyrosine phosphatase non-receptor type 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Matrix	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cytoplasmic Side Of Plasma Membrane Microtubule Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Germ Cell Development Spermatogenesis Cell Differentiation	MAPK Cascade Protein Dephosphorylation Signal Transduction
Pathways			Negative regulation of MAPK pathway Interleukin-37 signaling
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)	Basophil percentage of white cells ( 32888494) Breast cancer ( 23535733) Mean spheric corpuscular volume ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250	17 interacting genes: AATK APP CCDC57 EGFR EPHA2 ERBB3 ERBB4 GMCL1 IGF1R MAPK1 MAPK14 MAPK3 PPP1CA PRKACA PTK7 ROR2 SIRPA
Entrez ID		64395	5778
HPRD ID		13587	01480
Ensembl ID		ENSG00000087338	ENSG00000143851
Uniprot IDs		Q53SE7 Q96IK5	B4DZD9 P35236
PDB IDs			1ZC0 2A3K 2GP0 2GPH 2HVL 2QDC 2QDM 2QDP 3D42 3D44 3O4S 3O4T 3O4U
Enriched GO Terms of Interacting Partners?		Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process	Protein Kinase Activity Kinase Activity ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Transferase Activity Nucleotide Binding ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Cell Migration Regulation Of Cell Motility Animal Organ Development Regulation Of Signal Transduction Response To Epidermal Growth Factor Regulation Of Locomotion Regulation Of ERK1 And ERK2 Cascade Regulation Of Intracellular Signal Transduction Glial Cell Development MAP Kinase Activity Intracellular Signaling Cassette Schwann Cell Development Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Stress-activated MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Localization Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Interleukin-34-mediated Signaling Pathway Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis
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