PFKFB4

Gene Name		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity ATP Binding
	Biological Process	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Pathogenesis Dephosphorylation Small Molecule Metabolic Process Carbohydrate Phosphorylation
Pathways		Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-protein Interactions		3 interactors: CSNK2B GADD45A GSK3B
Entrez ID		5210
HPRD ID		05613
Ensembl ID		ENSG00000114268
Uniprot IDs		B7Z5C3 Q16877 Q5XLC2 Q5XLC3 Q66S35
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Mechanical Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cell Cycle Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Negative Regulation Of Protein Kinase Activity Response To Mechanical Stimulus Regulation Of Phosphorus Metabolic Process Negative Regulation Of Kinase Activity Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Binding Wnt Signaling Pathway Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Response To External Stimulus Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Cellular Response To Interleukin-3 Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Axon Guidance Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Localization To Microtubule Adiponectin-activated Signaling Pathway Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Negative Regulation Of Dendrite Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of NFAT Protein Import Into Nucleus ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Glycogen Biosynthetic Process Endothelial Tube Morphogenesis Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Axonogenesis
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