PFKFB4 and LRR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFKFB4	LRR1
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	leucine rich repeat protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex	Nucleus Cytosol
	Molecular Function	Nucleotide Binding Catalytic Activity 6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Hydrolase Activity	Protein Binding
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Gluconeogenesis Glycolytic Process Carbohydrate Phosphorylation	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Fructose-6-phosphate
Diseases
GWAS		Bitter beverage consumption ( 31046077) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Mental health study participation (completed survey) ( 31263887) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 25082827 28067908) Waist-hip index ( 34021172)
Interacting Genes		11 interacting genes: CCDC102B CDC23 CSNK2B FBXL7 FBXO28 GADD45A GSK3B LRR1 PJA1 THOC3 YBX1	9 interacting genes: CDKN1A MCM7 MTUS2 PFKFB4 PNMA2 TNFRSF9 TRIP13 UBC UBE2D1
Entrez ID		5210	122769
HPRD ID		05613	15164
Ensembl ID		ENSG00000114268	ENSG00000165501
Uniprot IDs		B7Z5C3 Q16877 Q5XLC3 Q66S35	A0A384MTQ0 Q96L50
PDB IDs			7PLO
Enriched GO Terms of Interacting Partners?		Protein Modification Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Protein Metabolic Process Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Protein Polyubiquitination Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Locomotion Negative Regulation Of Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body MiRNA Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of TORC2 Signaling Negative Regulation Of Dopaminergic Neuron Differentiation Regulation Of Glycogen (starch) Synthase Activity C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Proteolysis Negative Regulation Of Viral Life Cycle Release From Viral Latency Viral Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Macromolecule Catabolic Process Proteasomal Protein Catabolic Process TRNA Transport Histone Pre-mRNA 3'end Processing Complex
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