GLO1

Description		glyoxalase I
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Lactoylglutathione Lyase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Regulation Of Transcription By RNA Polymerase II Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways		Pyruvate metabolism
Drugs		Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-hydroxy-N-iodophenylcarbamoyl)glutathione Mercaptoethanol S-benzylglutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS		Blood protein levels ( 30072576) Major depressive disorder ( 29317602) Restless legs syndrome ( 29029846) Tuberculosis susceptibility in HIV infection ( 26942285)
Interacting Genes		5 interacting genes: CEBPA IKBKG MAP3K13 MEOX2 PJA1
Entrez ID		2739
HPRD ID		00730
Ensembl ID		ENSG00000124767
Uniprot IDs		Q04760 X5DNM4
PDB IDs		1BH5 1FRO 1QIN 1QIP 3VW9 3W0T 3W0U 7WSZ 7WT0 7WT1 7WT2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Homodimerization Activity Response To Vitamin B2 C/EBP Complex Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Branching Morphogenesis Of A Nerve IkappaB Kinase Complex Binding Positive Regulation Of Proteolysis CHOP-C/EBP Complex Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Somite Specification Regulation Of DNA-binding Transcription Factor Activity Linear Polyubiquitin Binding Regulation Of Branching Morphogenesis Of A Nerve Positive Regulation Of Neuron Maturation Protein Domain Specific Binding Response To Phenylpropanoid IkappaB Kinase Complex Fat Cell Proliferation Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Cell Maturation Regulation Of Neuron Maturation Urea Metabolic Process HMG Box Domain Binding Urea Cycle STAT Family Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Transferrin Receptor Binding Anoikis Response To Lithium Ion Regulation Of DNA-templated Transcription Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Regulation Of RNA Biosynthetic Process Protein Heterodimerization Activity Regulation Of Proteolysis Osteoblast Development Segment Specification Somite Development
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