GLO1

Gene Name		glyoxalase I
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Lactoylglutathione Lyase Activity Zinc Ion Binding
	Biological Process	Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process
Pathways
Drugs		Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione Beta-Mercaptoethanol S-Benzyl-Glutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS
Protein-protein Interactions		3 interactors: IKBKG MAP3K13 MEOX2
Entrez ID		2739
HPRD ID		00730
Ensembl ID		ENSG00000124767
Uniprot IDs		Q04760
PDB IDs		1BH5 1FRO 1QIN 1QIP 3VW9
Enriched GO Terms of Interacting Partners?		JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MAPK Cascade Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Somite Specification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Segment Specification Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Kinase Activity Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Modification Process B Cell Homeostasis NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Regulation Of RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		accelerate aggravate aggravating asp carboxy coactivators damages detoxifies epo erythropoiesis erythropoietin esa glu glycation glycative glyoxalse hif hypoxia impedes indoxyl master messenger posttranscriptional suppresses toxins transactivator tubules uremia uremic