GLO1 and MAP3K13

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GLO1	MAP3K13
Gene Name		glyoxalase I	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	IkappaB Kinase Complex Membrane
	Molecular Function	Lactoylglutathione Lyase Activity Zinc Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Carbohydrate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutathione Metabolic Process Methylglyoxal Metabolic Process Osteoclast Differentiation Negative Regulation Of Apoptotic Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs		Glutathione Indomethacin S-P-Nitrobenzyloxycarbonylglutathione S-(N-Hydroxy-N-Iodophenylcarbamoyl)Glutathione Beta-Mercaptoethanol S-Benzyl-Glutathione S-Hexylglutathione methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate
Diseases
GWAS			Airflow obstruction ( 22837378)
Protein-Protein Interactions		3 interactors: IKBKG MAP3K13 MEOX2	7 interactors: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3
Entrez ID		2739	9175
HPRD ID		00730	05372
Ensembl ID		ENSG00000124767	ENSG00000073803
Uniprot IDs		Q04760	O43283
PDB IDs		1BH5 1FRO 1QIN 1QIP 3VW9
Enriched GO Terms of Interacting Partners?		JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MAPK Cascade Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Somite Specification Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Regulation Of MAPK Cascade Segment Specification Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Kinase Activity Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein Modification Process B Cell Homeostasis NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 5 Signaling Pathway Regulation Of RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway	Regulation Of Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Response To Cytokine Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Organic Substance Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of JUN Kinase Activity JNK Cascade Defense Response Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Peptidyl-cysteine Oxidation Response To Tumor Necrosis Factor Positive Regulation Of Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of JNK Cascade Phosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Sorbitol Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Stress-activated MAPK Cascade Intracellular Receptor Signaling Pathway Regulation Of Immune Response
Tagcloud ?		accelerate aggravate aggravating asp carboxy coactivators damages detoxifies epo erythropoiesis erythropoietin esa glu glycation glycative glyoxalse hif hypoxia impedes indoxyl master messenger posttranscriptional suppresses toxins transactivator tubules uremia uremic
Tagcloud (Difference) ?		accelerate aggravate aggravating asp carboxy coactivators damages detoxifies epo erythropoiesis erythropoietin esa glu glycation glycative glyoxalse hif hypoxia impedes indoxyl master messenger posttranscriptional suppresses toxins transactivator tubules uremia uremic
Tagcloud (Intersection) ?