KIF9 and TRIM37

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		KIF9	TRIM37
Name		kinesin family member 9	tripartite motif containing 37
Structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytoskeleton Kinesin Complex Microtubule Cilium Motile Cilium Vesicle Sperm Flagellum Cell Projection	Chromosome Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity Identical Protein Binding	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H2AK119 Ubiquitin Ligase Activity
	Biological Process	Microtubule-based Movement Extracellular Matrix Disassembly Regulation Of Podosome Assembly Regulation Of Flagellated Sperm Motility Organelle Disassembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Monoubiquitination Protein Import Into Peroxisome Matrix Protein Ubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Negative Regulation Of Centriole Replication Protein Stabilization Protein Autoubiquitination Aggresome Assembly
Pathways		COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Adiponectin levels ( 31178129 ) Huntington's disease progression ( 28642124 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 ) Type 2 diabetes ( 30297969 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )	Cognitive function ( 25644384 ) General cognitive ability ( 29844566 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Testicular germ cell tumor ( 23666239 )
Interacting Genes		63 interacting genes: ACBD4 ALAS1 AMOTL2 ATP5IF1 BLZF1 CARD9 CCDC125 CYTIP DISC1 EFHC2 EMD FXR1 GOLGA6A HMBOX1 HOOK2 HSF2BP IHO1 IKZF1 IKZF3 INKA1 IQCB1 JAKMIP2 KANK2 KCTD9 KRT75 KRTAP10-3 KRTAP10-6 KRTAP10-9 LZTS1 LZTS2 MAD1L1 MID1 MID2 MIPOL1 NAB2 OIP5 OOEP PIBF1 PNMA5 PPP1R13B PRICKLE1 PRMT6 RBM48 RBM5 ROPN1 SHISA6 SLAIN1 SSX2IP STEEP1 TFIP11 TRIM27 TRIM37 TRIM54 VIM VPS52 ZBTB8A ZC2HC1C ZCCHC7 ZNF417 ZNF436 ZNF566 ZNF572 ZRANB1	76 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BASP1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DSCAM DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PABPC4 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655
Entrez ID		64147	4591
HPRD ID		07444	05463
Ensembl ID		ENSG00000088727	ENSG00000108395
Uniprot IDs		A8K932 Q6PJI1 Q9HAQ2	O94972
PDB IDs		3NWN	3LRQ
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Organelle Organization Microtubule Protein Localization To Cytoskeleton Microtubule-based Process Cytoskeleton Organization Microtubule Cytoskeleton Organization Intermediate Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament Zinc Ion Binding Wnt Signaling Pathway	Ubiquitin Conjugating Enzyme Activity Nucleus Thioesterase Binding Protein K48-linked Ubiquitination Signaling Adaptor Activity Protein Polyubiquitination Tumor Necrosis Factor Receptor Binding Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Binding Protein Ubiquitination Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Polynucleotide 3'-phosphatase Activity Regulation Of Gene Expression Positive Regulation Of NF-kappaB Transcription Factor Activity Protein K11-linked Ubiquitination Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process DNA Damage Response Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Post-translational Protein Modification Regulation Of Canonical NF-kappaB Signal Transduction Protein Monoubiquitination Elongin Complex Tumor Necrosis Factor Receptor Superfamily Complex ISG15 Transferase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Proteasomal Protein Catabolic Process Protein Autoubiquitination