SAA1 and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		SAA1	VKORC1
Gene Name		serum amyloid A1	vitamin K epoxide reductase complex, subunit 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region High-density Lipoprotein Particle Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Binding Heparin Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Receptor-mediated Endocytosis Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Formyl peptide receptors bind formyl peptides and many other ligands DEx/H-box helicases activate type I IFN and inflammatory cytokines production Amyloids Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Peptide ligand-binding receptors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane G alpha (i) signalling events Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA GPCR ligand binding MyD88-independent cascade G alpha (q) signalling events Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways GPCR downstream signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRAF6 mediated NF-kB activation Scavenging by Class B Receptors TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Amyloid A Levels ( 21124955)	Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		8 interactors: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 LAMA1 VIMP VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		6288	79001
HPRD ID		00097	10540
Ensembl ID		ENSG00000173432	ENSG00000167397
Uniprot IDs		P0DJI8	Q9BQB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Retinal Blood Vessel Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Retina Vasculature Morphogenesis In Camera-type Eye Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Retina Vasculature Development In Camera-type Eye Generation Of Neurons Neurogenesis Catabolic Process Cell Development Renal System Development Glomerulus Development Response To Stimulus Urogenital System Development Blood Vessel Morphogenesis Negative Regulation Of Angiogenesis Regulation Of Nitric Oxide Metabolic Process Nervous System Development Anatomical Structure Morphogenesis Blood Vessel Development Vasculature Development System Development Endothelial Cell Apoptotic Process Nephron Development Multicellular Organismal Development Organ Development Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?