SAA1 and FPR1

Number of citations of the paper that reports this interaction (PubMedID 10753626)
0

Data Source:
HPRD (in vitro)

		SAA1	FPR1
Description		serum amyloid A1	formyl peptide receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	G Protein-coupled Receptor Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding RAGE Receptor Binding
	Biological Process	Positive Regulation Of Cytokine Production Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Signaling
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-10 signaling Neutrophil degranulation
Drugs			Nedocromil
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576) Rosacea symptom severity ( 29771307)	Alopecia areata ( 25608926) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	5 interacting genes: ACTG1 ANXA1 GNAI2 GRK2 SAA1
Entrez ID		6288	2357
HPRD ID		00097	00646
Ensembl ID		ENSG00000173432	ENSG00000171051
Uniprot IDs		P0DJI8	P21462
PDB IDs		4IP8 4IP9 6MST 7ZKY	7EUO 7T6T 7VFX 7WVU
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Retinal Blood Vessel Morphogenesis Extracellular Structure Organization Extracellular Matrix Organization Retina Vasculature Morphogenesis In Camera-type Eye Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Signal Transduction Glucagon-like Peptide 1 Receptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity N-formyl Peptide Receptor Activity Derlin-1-VIMP Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Vessel Morphogenesis Glucagon Receptor Activity Laminin-1 Complex Laminin-3 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scavenger Receptor Binding Laminin Complex Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Multicellular Organismal Process Response To Psychosocial Stress Morphogenesis Of A Branching Epithelium Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Glycosphingolipid Binding Morphogenesis Of A Branching Structure Extracellular Region Negative Regulation Of Macrophage Apoptotic Process Complement Receptor Activity Cellular Response To Peptide Hormone Stimulus Post-translational Protein Targeting To Membrane, Translocation Derlin-1 Retrotranslocation Complex Regulation Of Basement Membrane Organization Molecular Adaptor Activity Negative Regulation Of Glycogen Biosynthetic Process Protein Complex Involved In Cell-matrix Adhesion	G Protein-coupled Receptor Binding G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Regulation Of Secretion By Cell Regulation Of Transport Negative Regulation Of Exocytosis Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Wound Healing Granulocyte Chemotaxis Basal Body Patch Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Actin Filament Granulocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Vesicle-mediated Transport Edg-2 Lysophosphatidic Acid Receptor Binding Regulation Of Interleukin-1 Production Mononuclear Cell Migration HLA-B Specific Inhibitory MHC Class I Receptor Activity Positive Regulation Of Locomotion Myeloid Leukocyte Migration Regulation Of Wound Healing Leukocyte Chemotaxis Negative Regulation Of Secretion By Cell Regulation Of Transepithelial Transport Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Myoblast Migration Involved In Skeletal Muscle Regeneration Positive Regulation Of Neutrophil Apoptotic Process Protein Localization To Bicellular Tight Junction Regulation Of Cell Adhesion Regulation Of Response To Wounding Dense Body Morphogenesis Of A Polarized Epithelium Cytoplasmic Side Of Mitochondrial Outer Membrane G Protein-coupled Receptor Signaling Pathway Regulation Of The Force Of Heart Contraction By Chemical Signal Alpha-2A Adrenergic Receptor Binding Desensitization Of G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Apoptotic Process Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Secretion Regulation Of Exocytosis Cell Chemotaxis Neutrophil Clearance
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