SAA1 and FPR1

Number of citations of the paper that reports this interaction (PMID 10753626)
15

Data Source:
HPRD (in vitro)

		SAA1	FPR1
Gene Name		serum amyloid A1	formyl peptide receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region High-density Lipoprotein Particle Extracellular Vesicular Exosome Endocytic Vesicle Lumen	Endosome Plasma Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Binding Heparin Binding	Receptor Activity N-formyl Peptide Receptor Activity Protein Binding RAGE Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Chemotaxis Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Toll Like Receptor 7/8 (TLR7/8) Cascade Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade Formyl peptide receptors bind formyl peptides and many other ligands DEx/H-box helicases activate type I IFN and inflammatory cytokines production Amyloids Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling Peptide ligand-binding receptors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane G alpha (i) signalling events Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA GPCR ligand binding MyD88-independent cascade G alpha (q) signalling events Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways GPCR downstream signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRAF6 mediated NF-kB activation Scavenging by Class B Receptors TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formyl peptide receptors bind formyl peptides and many other ligands
Drugs			Nedocromil
Diseases
GWAS		Amyloid A Levels ( 21124955)
Protein-Protein Interactions		8 interactors: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 LAMA1 VIMP VKORC1	5 interactors: ACTG1 ADRBK1 ANXA1 GNAI2 SAA1
Entrez ID		6288	2357
HPRD ID		00097	00646
Ensembl ID		ENSG00000173432
Uniprot IDs		P0DJI8	P21462
PDB IDs
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Chemotaxis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Neuron Projection Morphogenesis Retinal Blood Vessel Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Retina Vasculature Morphogenesis In Camera-type Eye Cell Morphogenesis Glomerular Basement Membrane Development Neuron Differentiation Cell Projection Organization Retina Vasculature Development In Camera-type Eye Generation Of Neurons Neurogenesis Catabolic Process Cell Development Renal System Development Glomerulus Development Response To Stimulus Urogenital System Development Blood Vessel Morphogenesis Negative Regulation Of Angiogenesis Regulation Of Nitric Oxide Metabolic Process Nervous System Development Anatomical Structure Morphogenesis Blood Vessel Development Vasculature Development System Development Endothelial Cell Apoptotic Process Nephron Development Multicellular Organismal Development Organ Development Negative Regulation Of Macrophage Apoptotic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell Activation Platelet Activation Defense Response Blood Coagulation Hemostasis Response To Stress Regulation Of Phospholipase Activity Regulation Of Body Fluid Levels Wound Healing Regulation Of Secretion Endocytosis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Neutrophil Clearance Response To Wounding Positive Regulation Of Transport Regulation Of Cytokine Secretion Immune System Process Innate Immune Response DNA Rewinding Positive Regulation Of Neutrophil Apoptotic Process Negative Regulation Of Phospholipase A2 Activity Regulation Of Cellular Localization Negative Regulation Of Interleukin-8 Secretion Prolactin Secretion Positive Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Phospholipase Activity Cell Surface Receptor Signaling Pathway Immune Response Negative Regulation Of Striated Muscle Contraction Regulation Of The Force Of Heart Contraction By Chemical Signal Cellular Response To Stimulus Homeostatic Process Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Tachykinin Receptor Signaling Pathway Vesicle-mediated Transport Positive Regulation Of Myeloid Cell Apoptotic Process Receptor-mediated Endocytosis Regulation Of Phospholipase A2 Activity Positive Regulation Of Catecholamine Secretion Movement Of Cell Or Subcellular Component DNA Strand Renaturation Arachidonic Acid Secretion Regulation Of Protein Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Adenosine Receptor Signaling Pathway Negative Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Secretion Inflammatory Response
Tagcloud ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fpr2 fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Difference) ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl isoforms mediterranean mobilization modulating predominant preference robust saa2 selectivity tlr2 tlr4lps toll	amplified c5a c5ar chromosomes complement contained digestion electrophoresis filters formylpeptides fprl2 fragment homologue hybridized il8ra il8rb kb kilobase library lie linkage mapped nylon probes pulsed restriction separated translated
Tagcloud (Intersection) ?		fpr2