SAA1 and COL4A1

Number of citations of the paper that reports this interaction (PubMedID 8995276)
0

Data Source:
HPRD (in vitro)

		SAA1	COL4A1
Description		serum amyloid A1	collagen type IV alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding
	Biological Process	Positive Regulation Of Cytokine Production Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases			Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576) Rosacea symptom severity ( 29771307)	Age-related nuclear cataracts ( 24951543) Arterial stiffness ( 20031579) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Coronary artery disease ( 32469254 33020668 24262325 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 31959993 29785010) Lateral ventricle volume ( 31530798) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Myocardial infarction ( 33532862 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Peripheral artery disease ( 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Stroke ( 30383316) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	30 interacting genes: ACHE APCS APP BGN BMP3 CD93 COL18A1 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI TGM2 THBS1
Entrez ID		6288	1282
HPRD ID		00097	00359
Ensembl ID		ENSG00000173432	ENSG00000187498
Uniprot IDs		P0DJI8	A5PKV2 P02462
PDB IDs		4IP8 4IP9 6MST 7ZKY	1LI1 5NAX 5NAY 6MPX
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Retinal Blood Vessel Morphogenesis Extracellular Structure Organization Extracellular Matrix Organization Retina Vasculature Morphogenesis In Camera-type Eye Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Signal Transduction Glucagon-like Peptide 1 Receptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity N-formyl Peptide Receptor Activity Derlin-1-VIMP Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Vessel Morphogenesis Glucagon Receptor Activity Laminin-1 Complex Laminin-3 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scavenger Receptor Binding Laminin Complex Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Multicellular Organismal Process Response To Psychosocial Stress Morphogenesis Of A Branching Epithelium Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Glycosphingolipid Binding Morphogenesis Of A Branching Structure Extracellular Region Negative Regulation Of Macrophage Apoptotic Process Complement Receptor Activity Cellular Response To Peptide Hormone Stimulus Post-translational Protein Targeting To Membrane, Translocation Derlin-1 Retrotranslocation Complex Regulation Of Basement Membrane Organization Molecular Adaptor Activity Negative Regulation Of Glycogen Biosynthetic Process Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Extracellular Matrix Basement Membrane Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Binding Acute-phase Response Extracellular Exosome Cell Adhesion Endoplasmic Reticulum Lumen Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis High-density Lipoprotein Particle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Glycosaminoglycan Binding Regulation Of Cell Adhesion Acute Inflammatory Response Platelet Alpha Granule Lumen Regulation Of Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Developmental Process Endodermal Cell Differentiation Calcium Ion Binding Golgi Lumen Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Proteoglycan Binding Response To Wounding Regulation Of Cell-substrate Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Neurogenesis Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Inflammatory Response Negative Regulation Of Platelet Activation Regulation Of Wound Healing Platelet Alpha Granule Positive Regulation Of Cell Communication Positive Regulation Of Signaling Laminin Binding Negative Regulation Of Wound Healing Bone Development Positive Regulation Of Nervous System Development
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