SAA1 and COL4A3

Number of citations of the paper that reports this interaction (PubMedID 8995276)
0

Data Source:
HPRD (in vitro)

		SAA1	COL4A3
Description		serum amyloid A1	collagen type IV alpha 3 chain
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Positive Regulation Of Cytokine Production Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576) Rosacea symptom severity ( 29771307)	Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 29760442 31798171 32528159) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		6288	1285
HPRD ID		00097	00354
Ensembl ID		ENSG00000173432	ENSG00000169031
Uniprot IDs		P0DJI8	Q01955
PDB IDs		4IP8 4IP9 6MST 7ZKY	5NB0 6WKU
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Retinal Blood Vessel Morphogenesis Extracellular Structure Organization Extracellular Matrix Organization Retina Vasculature Morphogenesis In Camera-type Eye Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Signal Transduction Glucagon-like Peptide 1 Receptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity N-formyl Peptide Receptor Activity Derlin-1-VIMP Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Vessel Morphogenesis Glucagon Receptor Activity Laminin-1 Complex Laminin-3 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scavenger Receptor Binding Laminin Complex Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Multicellular Organismal Process Response To Psychosocial Stress Morphogenesis Of A Branching Epithelium Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Glycosphingolipid Binding Morphogenesis Of A Branching Structure Extracellular Region Negative Regulation Of Macrophage Apoptotic Process Complement Receptor Activity Cellular Response To Peptide Hormone Stimulus Post-translational Protein Targeting To Membrane, Translocation Derlin-1 Retrotranslocation Complex Regulation Of Basement Membrane Organization Molecular Adaptor Activity Negative Regulation Of Glycogen Biosynthetic Process Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion
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