SAA1 and GLP1R

Number of citations of the paper that reports this interaction (PubMedID 28597972)
0

Data Source:
BioGRID (protein complementation assay)

		SAA1	GLP1R
Description		serum amyloid A1	glucagon like peptide 1 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Glucagon Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Signaling Receptor Activity Glucagon-like Peptide 1 Receptor Activity
	Biological Process	Positive Regulation Of Cytokine Production Acute-phase Response Positive Regulation Of Cytosolic Calcium Ion Concentration Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Hormone Secretion Regulation Of Biological Quality Cellular Response To Glucagon Stimulus Response To Psychosocial Stress
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors
Drugs			Glucagon Exenatide Liraglutide Albiglutide Dulaglutide Lixisenatide Semaglutide Taspoglutide Tirzepatide Efpeglenatide Glutazumab
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576) Rosacea symptom severity ( 29771307)	Blood sugar levels ( 29403010) Fasting blood glucose ( 25631608) Fasting blood glucose adjusted for BMI ( 25625282) Fasting glucose ( 34059833) Type 2 diabetes ( 32499647)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	112 interacting genes: ACSF3 AGXT AIG1 APH1A ARFRP1 ARLN ASGR2 ATP13A1 ATP5MC3 ATP6AP2 C18orf32 CALM1 CAND2 CAV1 CCDC167 CD63 CD81 CELA3B CEND1 CFI CLDN7 CLIP4 CLPS CNIH4 COMT CYSRT1 CYSTM1 DAD1 DHRS7 EBP ELOVL1 EMC7 EMP2 ERP29 FGL1 FTL GABBR2 GCG GJB1 GNAS GP2 GPR108 GPR37 GPRASP1 GRINA HAMP HPN IER3 IFITM3 KHK KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP5-9 LAPTM4A LINC00269 MRPL22 MT-ATP6 MT-ND4L MTCH2 MYL6 NBPF19 NOTCH2NLA NRGN NUCKS1 OCIAD2 OST4 P4HTM PAM PAQR6 PGRMC1 PIGG POMT2 PPIB PRSS2 PSMD8 RAB5B RAB5C RNF5 RTN3 RTN4 RTRAF SAA1 SCGB2A1 SEC11C SELENOK SERPINA1 SLC15A4 SLC37A4 SLC61A1 SLC9D1 SPTSSA STMN1 STMN3 STOML2 SVOP SYNGR3 SYNGR4 SYS1 TM4SF4 TMBIM6 TMEM147 TMEM176B TOMM6 TSPAN13 UGT1A9 VAPB ZNF99
Entrez ID		6288	2740
HPRD ID		00097	00677
Ensembl ID		ENSG00000173432	ENSG00000112164
Uniprot IDs		P0DJI8	A0A142FHB8 P43220
PDB IDs		4IP8 4IP9 6MST 7ZKY	3C59 3C5T 3IOL 4ZGM 5E94 5NX2 5OTT 5OTU 5OTV 5OTW 5OTX 5VEW 5VEX 6B3J 6GB1 6ORV 6VCB 6X18 6X19 6X1A 6XOX 7C2E 7DUQ 7DUR 7E14 7EVM 7FIM 7KI0 7KI1 7LCI 7LCJ 7LCK 7LLL 7LLY 7RG9 7RGP 7RTB 7S15 7S1M 7S3I 7VBH 7VBI 7X8R 7X8S 8JIP 8JIR 8JIS 8WG7 8YW3 9IVG 9IVM 9J1P
Enriched GO Terms of Interacting Partners?		Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Extracellular Matrix Retinal Blood Vessel Morphogenesis Extracellular Structure Organization Extracellular Matrix Organization Retina Vasculature Morphogenesis In Camera-type Eye Glomerular Basement Membrane Development Cell Surface Receptor Signaling Pathway Signal Transduction Glucagon-like Peptide 1 Receptor Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity N-formyl Peptide Receptor Activity Derlin-1-VIMP Complex Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Blood Vessel Morphogenesis Glucagon Receptor Activity Laminin-1 Complex Laminin-3 Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Scavenger Receptor Binding Laminin Complex Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Multicellular Organismal Process Response To Psychosocial Stress Morphogenesis Of A Branching Epithelium Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Glycosphingolipid Binding Morphogenesis Of A Branching Structure Extracellular Region Negative Regulation Of Macrophage Apoptotic Process Complement Receptor Activity Cellular Response To Peptide Hormone Stimulus Post-translational Protein Targeting To Membrane, Translocation Derlin-1 Retrotranslocation Complex Regulation Of Basement Membrane Organization Molecular Adaptor Activity Negative Regulation Of Glycogen Biosynthetic Process Protein Complex Involved In Cell-matrix Adhesion	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Intermediate Filament Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Keratin Filament Neutrophil Migration Host-mediated Activation Of Viral Process Endoplasmic Reticulum Membrane Organization Chemical Homeostasis Intracellular Chemical Homeostasis Synaptic Vesicle Membrane Intracellular Calcium Ion Homeostasis Intracellular Monoatomic Cation Homeostasis Granulocyte Migration
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